About PiggyBac transposable element-derived protein 5
PiggyBac transposable element-derived protein 5 (PGBD5) is a protein
from Homo sapiens identified by UniProt accession
Q8N414, 524 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | PiggyBac transposable element-derived protein 5 |
|---|
| UniProt accession | Q8N414 |
|---|
| Gene | PGBD5 |
|---|
| Organism | Homo sapiens |
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| Length | 524 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (41)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.26
- Red cell distribution width · score 0.13
- high density lipoprotein cholesterol measurement · score 0.12
- apolipoprotein A 1 measurement · score 0.12
- triglyceride measurement · score 0.12
- neoplasm · score 0.10
- Mobius syndrome · score 0.07
- malignant rhabdoid tumour · score 0.07
- papillary thyroid carcinoma · score 0.04
- atypical teratoid rhabdoid tumor · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N414-F1 | alphafold | PREDICTED | 80.63 | — |
Amino-acid sequence (524 residues)
MAEGGGGARR RAPALLEAAR ARYESLHISD DVFGESGPDS GGNPFYSTSA ASRSSSAASS DDEREPPGPP GAAPPPPRAP DAQEPEEDEA GAGWSAALRD RPPPRFEDTG GPTRKMPPSA SAVDFFQLFV PDNVLKNMVV QTNMYAKKFQ ERFGSDGAWV EVTLTEMKAF LGYMISTSIS HCESVLSIWS GGFYSNRSLA LVMSQARFEK ILKYFHVVAF RSSQTTHGLY KVQPFLDSLQ NSFDSAFRPS QTQVLHEPLI DEDPVFIATC TERELRKRKK RKFSLWVRQC SSTGFIIQIY VHLKEGGGPD GLDALKNKPQ LHSMVARSLC RNAAGKNYII FTGPSITSLT LFEEFEKQGI YCCGLLRARK SDCTGLPLSM LTNPATPPAR GQYQIKMKGN MSLICWYNKG HFRFLTNAYS PVQQGVIIKR KSGEIPCPLA VEAFAAHLSY ICRYDDKYSK YFISHKPNKT WQQVFWFAIS IAINNAYILY KMSDAYHVKR YSRAQFGERL VRELLGLEDA SPTH
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