About Leukocyte immunoglobulin-like receptor subfamily B member 2
Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) is a protein
from Homo sapiens identified by UniProt accession
Q8N423, 597 residues long.
MolForge cross-references it against 0 known binders and
219 disease associations.
Target properties
| Protein name | Leukocyte immunoglobulin-like receptor subfamily B member 2 |
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| UniProt accession | Q8N423 |
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| Gene | LILRB2 |
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| Organism | Homo sapiens |
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| Length | 597 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (219)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.37
- blood protein measurement · score 0.37
- total cholesterol measurement · score 0.31
- apolipoprotein A 1 measurement · score 0.30
- erythrocyte count · score 0.24
- alcohol drinking · score 0.21
- alcohol consumption measurement · score 0.20
- Red cell distribution width · score 0.20
- Takayasu arteritis · score 0.19
- creatine kinase measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N423-F1 | alphafold | PREDICTED | 75.85 | — |
Amino-acid sequence (597 residues)
MTPIVTVLIC LGLSLGPRTR VQTGTIPKPT LWAEPDSVIT QGSPVTLSCQ GSLEAQEYRL YREKKSASWI TRIRPELVKN GQFHIPSITW EHTGRYGCQY YSRARWSELS DPLVLVMTGA YPKPTLSAQP SPVVTSGGRV TLQCESQVAF GGFILCKEGE DEHPQCLNSQ PHARGSSRAI FSVGPVSPNR RWSHRCYGYD LNSPYVWSSP SDLLELLVPG VSKKPSLSVQ PGPVMAPGES LTLQCVSDVG YDRFVLYKEG ERDLRQLPGR QPQAGLSQAN FTLGPVSRSY GGQYRCYGAH NLSSECSAPS DPLDILITGQ IRGTPFISVQ PGPTVASGEN VTLLCQSWRQ FHTFLLTKAG AADAPLRLRS IHEYPKYQAE FPMSPVTSAH AGTYRCYGSL NSDPYLLSHP SEPLELVVSG PSMGSSPPPT GPISTPGPED QPLTPTGSDP QSGLGRHLGV VIGILVAVVL LLLLLLLLFL ILRHRRQGKH WTSTQRKADF QHPAGAVGPE PTDRGLQWRS SPAADAQEEN LYAAVKDTQP EDGVEMDTRA AASEAPQDVT YAQLHSLTLR RKATEPPPSQ EREPPAEPSI YATLAIH
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