Ras-GEF domain-containing family member 1C (RASGEF1C)

About Ras-GEF domain-containing family member 1C

Ras-GEF domain-containing family member 1C (RASGEF1C) is a protein from Homo sapiens identified by UniProt accession Q8N431, 466 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	Ras-GEF domain-containing family member 1C
UniProt accession	Q8N431
Gene	RASGEF1C
Organism	Homo sapiens
Length	466 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

FEV/FVC ratio · score 0.44
cortical surface area measurement · score 0.35
peak expiratory flow · score 0.33
cortical thickness · score 0.24
forced expiratory volume · score 0.20
brain measurement · score 0.19
adolescent idiopathic scoliosis · score 0.03
COVID-19 · score 0.01
major depressive disorder · score 0.01
attention deficit hyperactivity disorder · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N431-F1	alphafold	PREDICTED	85.50	—

Amino-acid sequence (466 residues)

MPQTLSASDM VTPGSLSPPP TEPTDGEQAG QPLLDGAPSS ASLETLIQHL VPTADYYPEK AYIFTFLLSS RLFIEPRELL ARVCHLCIEQ QQLDKPVLDK ARVRKFGPKL LQLLAEWTET FPRDFQEEST IGHLKDVVGR IAPCDEAYRK RMHQLLQALH QKLAALRQGP EGLVGADKPI SYRTKPPASI HRELLGVCSD PYTLAQQLTH VELERLRHIG PEEFVQAFVN KDPLASTKPC FSDKTSNLEA YVKWFNRLCY LVATEICMPA KKKQRAQVIE FFIDVARECF NIGNFNSLMA IISGMNMSPV SRLKKTWAKV RTAKFFILEH QMDPTGNFCN YRTALRGAAH RSLTAHSSRE KIVIPFFSLL IKDIYFLNEG CANRLPNGHV NFEKFLELAK QVGEFITWKQ VECPFEQDAS ITHYLYTAPI FSEDGLYLAS YESESPENQT EKERWKALRS SILGKT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards