About Translation factor GUF1, mitochondrial
Translation factor GUF1, mitochondrial (GUF1) is a protein
from Homo sapiens identified by UniProt accession
Q8N442, 669 residues long.
MolForge cross-references it against 0 known binders and
179 disease associations.
Target properties
| Protein name | Translation factor GUF1, mitochondrial |
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| UniProt accession | Q8N442 |
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| Gene | GUF1 |
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| Organism | Homo sapiens |
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| Length | 669 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (179)
Diseases linked to this target (Open Targets).
- West syndrome · score 0.52
- body mass index · score 0.11
- body height · score 0.11
- Abnormality of refraction · score 0.10
- risk-taking behaviour · score 0.10
- obesity · score 0.09
- appendicular lean mass · score 0.09
- C-reactive protein measurement · score 0.09
- PHF-tau measurement · score 0.09
- self reported educational attainment · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N442-F1 | alphafold | PREDICTED | 81.61 | — |
Amino-acid sequence (669 residues)
MWTLVGRGWG CARALAPRAT GAALLVAPGP RSAPTLGAAP ESWATDRLYS SAEFKEKLDM SRFPVENIRN FSIVAHVDHG KSTLADRLLE LTGTIDKTKN NKQVLDKLQV ERERGITVKA QTASLFYNCE GKQYLLNLID TPGHVDFSYE VSRSLSACQG VLLVVDANEG IQAQTVANFF LAFEAQLSVI PVINKIDLKN ADPERVENQI EKVFDIPSDE CIKISAKLGT NVESVLQAII ERIPPPKVHR KNPLRALVFD STFDQYRGVI ANVALFDGVV SKGDKIVSAH TQKTYEVNEV GVLNPNEQPT HKLYAGQVGY LIAGMKDVTE AQIGDTLCLH KQPVEPLPGF KSAKPMVFAG MYPLDQSEYN NLKSAIEKLT LNDSSVTVHR DSSLALGAGW RLGFLGLLHM EVFNQRLEQE YNASVILTTP TVPYKAVLSS SKLIKEHREK EITIINPAQF PDKSKVTEYL EPVVLGTIIT PDEYTGKIMM LCEARRAVQK NMIFIDQNRV MLKYLFPLNE IVVDFYDSLK SLSSGYASFD YEDAGYQTAE LVKMDILLNG NTVEELVTVV HKDKAHSIGK AICERLKDSL PRQLFEIAIQ AAIGSKIIAR ETVKAYRKNV LAKCYGGDIT RKMKLLKRQA EGKKKLRKIG NVEVPKDAFI KVLKTQSSK
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