About Ligand of Numb protein X 2
Ligand of Numb protein X 2 (LNX2) is a protein
from Homo sapiens identified by UniProt accession
Q8N448, 690 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | Ligand of Numb protein X 2 |
|---|
| UniProt accession | Q8N448 |
|---|
| Gene | LNX2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 690 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (23)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.40
- platelet component distribution width · score 0.37
- platelet count · score 0.32
- diet measurement · score 0.26
- mathematical ability · score 0.20
- age at first sexual intercourse measurement · score 0.07
- alcohol consumption measurement · score 0.06
- childhood trauma measurement · score 0.06
- Red cell distribution width · score 0.05
- type 2 diabetes mellitus · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N448-F1 | alphafold | PREDICTED | 74.60 | — |
Amino-acid sequence (690 residues)
MGTTSDEMVS VEQTSSSSLN PLCFECGQQH WTRENHLYNY QNEVDDDLVC HICLQPLLQP LDTPCGHTFC YKCLRNFLQE KDFCPLDRKR LHFKLCKKSS ILVHKLLDKL LVLCPFSSVC KDVMQRCDLE AHLKNRCPGA SHRRVALERR KTSRTQAEIE NENGPTLLDP AGTLSPEADC LGTGAVPVER HLTSASLSTW SEEPGLDNPA FEESAGADTT QQPLSLPEGE ITTIEIHRSN PYIQLGISIV GGNETPLINI VIQEVYRDGV IARDGRLLAG DQILQVNNYN ISNVSHNYAR AVLSQPCNTL HLTVLRERRF GNRAHNHSDS NSPREEIFQV ALHKRDSGEQ LGIKLVRRTD EPGVFILDLL EGGLAAQDGR LSSNDRVLAI NGHDLKYGTP ELAAQIIQAS GERVNLTIAR PGKPQPGNTI REAGNHSSSS QHHTPPPYYS RPSSHKDLTQ CVTCQEKHIT VKKEPHESLG MTVAGGRGSK SGELPIFVTS VPPHGCLARD GRIKRGDVLL NINGIDLTNL SHSEAVAMLK ASAASPAVAL KALEVQIVEE ATQNAEEQPS TFSENEYDAS WSPSWVMWLG LPSTLHSCHD IVLRRSYLGS WGFSIVGGYE ENHTNQPFFI KTIVLGTPAY YDGRLKCGDM IVAVNGLSTV GMSHSALVPM LKEQRNKVTL TVICWPGSLV
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