Leucine-rich repeat-containing protein 18 (LRRC18)

About Leucine-rich repeat-containing protein 18

Leucine-rich repeat-containing protein 18 (LRRC18) is a protein from Homo sapiens identified by UniProt accession Q8N456, 261 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 18
UniProt accession	Q8N456
Gene	LRRC18
Organism	Homo sapiens
Length	261 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.31
systemic lupus erythematosus · score 0.27
rheumatoid arthritis · score 0.19
adolescent idiopathic scoliosis · score 0.17
primary biliary cirrhosis · score 0.13
clinically amyopathic dermatomyositis · score 0.10
Red cell distribution width · score 0.08
monocyte count · score 0.07
HbA1c measurement · score 0.07
drug use measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N456-F1	alphafold	PREDICTED	82.06	—

Amino-acid sequence (261 residues)

MVKGEKGPKG KKITLKVARN CIKITFDGKK RLDLSKMGIT TFPKCILRLS DMDELDLSRN LIRKIPDSIS KFQNLRWLDL HSNYIDKLPE SIGQMTSLLY LNVSNNRLTS NGLPVELKQL KNIRAVNLGL NHLDSVPTTL GALKELHEVG LHDNLLNNIP VSISKLPKLK KLNIKRNPFP KPGESEIFID SIRRLENLYV VEEKDLCAAC LRKCQNARDN LNRIKNMATT TPRKTIFPNL ISPNSMAKDS WEDWRIRLTS S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards