F-box/LRR-repeat protein 16 (FBXL16)

About F-box/LRR-repeat protein 16

F-box/LRR-repeat protein 16 (FBXL16) is a protein from Homo sapiens identified by UniProt accession Q8N461, 479 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	F-box/LRR-repeat protein 16
UniProt accession	Q8N461
Gene	FBXL16
Organism	Homo sapiens
Length	479 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.29
clear cell renal carcinoma · score 0.19
smoking behavior · score 0.11
appendicular lean mass · score 0.10
smoking status measurement · score 0.09
self reported educational attainment · score 0.08
mathematical ability · score 0.08
smoking behaviour measurement · score 0.07
platelet count · score 0.05
smoking initiation · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N461-F1	alphafold	PREDICTED	83.18	—

Amino-acid sequence (479 residues)

MSSPGIDGDP KPPCLPRNGL VKLPGQPNGL GAASITKGTP ATKNRPCQPP PPPTLPPPSL AAPLSRAALA GGPCTPAGGP ASALAPGHPA ERPPLATDEK ILNGLFWYFS ACEKCVLAQV CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL PGGEKEFVNL QGFAARGFEG FCLVGVSDLD ICEFIDNYAL SKKGVKAMSL KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL SARITSLSVS DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR LLSCWEITNH GVVNVVHSLP NLTALSLSGC SKVTDDGVEL VAENLRKLRS LDLSWCPRIT DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR SLYLRWCCQV QDFGLKHLLA LGSLRLLSLA GCPLLTTTGL SGLVQLQELE ELELTNCPGA TPELFKYFSQ HLPRCLVIE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards