About D-2-hydroxyglutarate dehydrogenase, mitochondrial
D-2-hydroxyglutarate dehydrogenase, mitochondrial (D2HGDH) is a protein
from Homo sapiens identified by UniProt accession
Q8N465, 521 residues long.
MolForge cross-references it against 0 known binders and
78 disease associations.
Target properties
| Protein name | D-2-hydroxyglutarate dehydrogenase, mitochondrial |
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| UniProt accession | Q8N465 |
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| Gene | D2HGDH |
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| Organism | Homo sapiens |
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| Length | 521 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (78)
Diseases linked to this target (Open Targets).
- D-2-hydroxyglutaric aciduria · score 0.73
- asthma · score 0.43
- allergic disease · score 0.38
- eosinophil count · score 0.38
- Generalized non-motor (absence) seizure · score 0.37
- Bilateral tonic-clonic seizure · score 0.37
- cancer antigen 125 measurement · score 0.36
- Eczematoid dermatitis · score 0.35
- serum metabolite measurement · score 0.33
- glioma · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N465-F1 | alphafold | PREDICTED | 92.37 | — |
Amino-acid sequence (521 residues)
MLPRRPLAWP AWLLRGAPGA AGSWGRPVGP LARRGCCSAP GTPEVPLTRE RYPVRRLPFS TVSKQDLAAF ERIVPGGVVT DPEALQAPNV DWLRTLRGCS KVLLRPRTSE EVSHILRHCH ERNLAVNPQG GNTGMVGGSV PVFDEIILST ARMNRVLSFH SVSGILVCQA GCVLEELSRY VEERDFIMPL DLGAKGSCHI GGNVATNAGG LRFLRYGSLH GTVLGLEVVL ADGTVLDCLT SLRKDNTGYD LKQLFIGSEG TLGIITTVSI LCPPKPRAVN VAFLGCPGFA EVLQTFSTCK GMLGEILSAF EFMDAVCMQL VGRHLHLASP VQESPFYVLI ETSGSNAGHD AEKLGHFLEH ALGSGLVTDG TMATDQRKVK MLWALRERIT EALSRDGYVY KYDLSLPVER LYDIVTDLRA RLGPHAKHVV GYGHLGDGNL HLNVTAEAFS PSLLAALEPH VYEWTAGQQG SVSAEHGVGF RKRDVLGYSK PPGALQLMQQ LKALLDPKGI LNPYKTLPSQ A
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