Secreted frizzled-related protein 1 (SFRP1)

About Secreted frizzled-related protein 1

Secreted frizzled-related protein 1 (SFRP1) is a protein from Homo sapiens identified by UniProt accession Q8N474, 314 residues long. MolForge cross-references it against 0 known binders and 350 disease associations.

Target properties

Protein name	Secreted frizzled-related protein 1
UniProt accession	Q8N474
Gene	SFRP1
Organism	Homo sapiens
Length	314 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (350)

Diseases linked to this target (Open Targets).

body height · score 0.39
electrocardiography · score 0.38
FEV/FVC ratio · score 0.36
cortical surface area measurement · score 0.35
cortical thickness · score 0.34
sitting height measurement · score 0.29
brain measurement · score 0.28
metabolite measurement · score 0.28
PHF-tau measurement · score 0.28
blood protein measurement · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N474-F1	alphafold	PREDICTED	79.64	—

Amino-acid sequence (314 residues)

MGIGRSEGGR RGAALGVLLA LGAALLAVGS ASEYDYVSFQ SDIGPYQSGR FYTKPPQCVD IPADLRLCHN VGYKKMVLPN LLEHETMAEV KQQASSWVPL LNKNCHAGTQ VFLCSLFAPV CLDRPIYPCR WLCEAVRDSC EPVMQFFGFY WPEMLKCDKF PEGDVCIAMT PPNATEASKP QGTTVCPPCD NELKSEAIIE HLCASEFALR MKIKEVKKEN GDKKIVPKKK KPLKLGPIKK KDLKKLVLYL KNGADCPCHQ LDNLSHHFLI MGRKVKSQYL LTAIHKWDKK NKEFKNFMKK MKNHECPTFQ SVFK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards