About Follistatin-related protein 5
Follistatin-related protein 5 (FSTL5) is a protein
from Homo sapiens identified by UniProt accession
Q8N475, 847 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Follistatin-related protein 5 |
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| UniProt accession | Q8N475 |
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| Gene | FSTL5 |
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| Organism | Homo sapiens |
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| Length | 847 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (39)
Diseases linked to this target (Open Targets).
- body mass index · score 0.46
- bipolar disorder · score 0.37
- risky sexual behaviour measurement · score 0.36
- alcohol dependence · score 0.36
- inflammatory biomarker measurement · score 0.28
- attention deficit hyperactivity disorder · score 0.26
- autism spectrum disorder · score 0.26
- unipolar depression · score 0.26
- waist circumference · score 0.23
- PHF-tau measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N475-F1 | alphafold | PREDICTED | 83.67 | — |
Amino-acid sequence (847 residues)
MFKCWSVVLV LGFIFLESEG RPTKEGGYGL KSYQPLMRLR HKQEKNQESS RVKGFMIQDG PFGSCENKYC GLGRHCVTSR ETGQAECACM DLCKRHYKPV CGSDGEFYEN HCEVHRAACL KKQKITIVHN EDCFFKGDKC KTTEYSKMKN MLLDLQNQKY IMQENENPNG DDISRKKLLV DQMFKYFDAD SNGLVDINEL TQVIKQEELG KDLFDCTLYV LLKYDDFNAD KHLALEEFYR AFQVIQLSLP EDQKLSITAA TVGQSAVLSC AIQGTLRPPI IWKRNNIILN NLDLEDINDF GDDGSLYITK VTTTHVGNYT CYADGYEQVY QTHIFQVNVP PVIRVYPESQ AREPGVTASL RCHAEGIPKP QLGWLKNGID ITPKLSKQLT LQANGSEVHI SNVRYEDTGA YTCIAKNEAG VDEDISSLFV EDSARKTLAN ILWREEGLGI GNMFYVFYED GIKVIQPIEC EFQRHIKPSE KLLGFQDEVC PKAEGDEVQR CVWASAVNVK DKFIYVAQPT LDRVLIVDVQ SQKVVQAVST DPVPVKLHYD KSHDQVWVLS WGTLEKTSPT LQVITLASGN VPHHTIHTQP VGKQFDRVDD FFIPTTTLII THMRFGFILH KDEAALQKID LETMSYIKTI NLKDYKCVPQ SLAYTHLGGY YFIGCKPDST GAVSPQVMVD GVTDSVIGFN SDVTGTPYVS PDGHYLVSIN DVKGLVRVQY ITIRGEIQEA FDIYTNLHIS DLAFQPSFTE AHQYNIYGSS STQTDVLFVE LSSGKVKMIK SLKEPLKAEE WPWNRKNRQI QDSGLFGQYL MTPSKDSLFI LDGRLNKLNC EITEVEKGNT VIWVGDA
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