Protein limb expression 1 homolog (LIX1)

About Protein limb expression 1 homolog

Protein limb expression 1 homolog (LIX1) is a protein from Homo sapiens identified by UniProt accession Q8N485, 282 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Protein limb expression 1 homolog
UniProt accession	Q8N485
Gene	LIX1
Organism	Homo sapiens
Length	282 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

gastrointestinal stromal tumor · score 0.10
sleep duration · score 0.10
triglyceride measurement · score 0.10
severe malarial anemia · score 0.03
endoplasmic reticulum aminopeptidase 1 measurement · score 0.03
drug use measurement · score 0.02
low density lipoprotein cholesterol measurement · score 0.02
medulloblastoma · score 0.02
neoplasm · score 0.02
spinal muscular atrophy · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N485-F1	alphafold	PREDICTED	85.52	—

Amino-acid sequence (282 residues)

MDRTLESLRH IIAQVLPHRD PALVFKDLNV VSMLQEFWES KQQQKAAFPS EGVVVYESLP APGPPFVSYV TLPGGSCFGN FQCCLSRAEA RRDAAKVALI NSLFNELPSR RITKEFIMES VQEAVASTSG TLDDADDPST SVGAYHYMLE SNMGKTMLEF QELMTIFQLL HWNGSLKALR ETKCSRQEVI SYYSQYSLDE KMRSHMALDW IMKERDSPGI VSQELRMALR QLEEARKAGQ ELRFYKEKKE ILSLALTQIC SDPDTSSPSD DQLSLTALCG YH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards