About RING1 and YY1-binding protein
RING1 and YY1-binding protein (RYBP) is a protein
from Homo sapiens identified by UniProt accession
Q8N488, 228 residues long.
MolForge cross-references it against 0 known binders and
196 disease associations.
Target properties
| Protein name | RING1 and YY1-binding protein |
|---|
| UniProt accession | Q8N488 |
|---|
| Gene | RYBP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 228 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (196)
Diseases linked to this target (Open Targets).
- body height · score 0.44
- BMI-adjusted waist circumference · score 0.43
- monocyte count · score 0.40
- platelet count · score 0.40
- hemoglobin measurement · score 0.39
- hematocrit · score 0.38
- lean body mass · score 0.38
- mean platelet volume · score 0.37
- Eczematoid dermatitis · score 0.37
- platelet crit · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N488-F1 | alphafold | PREDICTED | 66.64 | — |
Amino-acid sequence (228 residues)
MTMGDKKSPT RPKRQAKPAA DEGFWDCSVC TFRNSAEAFK CSICDVRKGT STRKPRINSQ LVAQQVAQQY ATPPPPKKEK KEKVEKQDKE KPEKDKEISP SVTKKNTNKK TKPKSDILKD PPSEANSIQS ANATTKTSET NHTSRPRLKN VDRSTAQQLA VTVGNVTVII TDFKEKTRSS STSSSTVTSS AGSEQQNQSS SGSESTDKGS SRSSTPKGDM SAVNDESF
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