About Probable thioesterase PNKD
Probable thioesterase PNKD (PNKD) is a protein
from Homo sapiens identified by UniProt accession
Q8N490, 385 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Probable thioesterase PNKD |
|---|
| UniProt accession | Q8N490 |
|---|
| Gene | PNKD |
|---|
| Organism | Homo sapiens |
|---|
| Length | 385 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (84)
Diseases linked to this target (Open Targets).
- paroxysmal nonkinesigenic dyskinesia 1 · score 0.76
- paroxysmal nonkinesigenic dyskinesia · score 0.63
- Episodic hemiplegia · score 0.33
- paroxysmal dystonia · score 0.33
- paroxysmal dyskinesia · score 0.33
- systolic blood pressure · score 0.30
- lean body mass · score 0.28
- leukocyte count · score 0.27
- serum gamma-glutamyl transferase measurement · score 0.27
- Red cell distribution width · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N490-F1 | alphafold | PREDICTED | 82.99 | — |
Amino-acid sequence (385 residues)
MAAVVAATAL KGRGARNARV LRGILAGATA NKASHNRTRA LQSHSSPEGK EEPEPLSPEL EYIPRKRGKN PMKAVGLAWY SLYTRTWLGY LFYRQQLRRA RNRYPKGHSK TQPRLFNGVK VLPIPVLSDN YSYLIIDTQA QLAVAVDPSD PRAVQASIEK EGVTLVAILC THKHWDHSGG NRDLSRRHRD CRVYGSPQDG IPYLTHPLCH QDVVSVGRLQ IRALATPGHT QGHLVYLLDG EPYKGPSCLF SGDLLFLSGC GRTFEGNAET MLSSLDTVLG LGDDTLLWPG HEYAEENLGF AGVVEPENLA RERKMQWVQR QRLERKGTCP STLGEERSYN PFLRTHCLAL QEALGPGPGP TGDDDYSRAQ LLEELRRLKD MHKSK
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