BPI fold-containing family B member 2 (BPIFB2)

About BPI fold-containing family B member 2

BPI fold-containing family B member 2 (BPIFB2) is a protein from Homo sapiens identified by UniProt accession Q8N4F0, 458 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.

Target properties

Protein name	BPI fold-containing family B member 2
UniProt accession	Q8N4F0
Gene	BPIFB2
Organism	Homo sapiens
Length	458 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (36)

Diseases linked to this target (Open Targets).

lung adenocarcinoma · score 0.19
ovarian cancer · score 0.18
glioblastoma multiforme · score 0.17
endometrial cancer · score 0.15
squamous cell lung carcinoma · score 0.14
head and neck squamous cell carcinoma · score 0.12
hair colour measurement · score 0.04
non-small cell lung carcinoma · score 0.04
neoplasm · score 0.02
blood protein measurement · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N4F0-F1	alphafold	PREDICTED	88.84	—

Amino-acid sequence (458 residues)

MAWASRLGLL LALLLPVVGA STPGTVVRLN KAALSYVSEI GKAPLQRALQ VTVPHFLDWS GEALQPTRIR ILNVHVPRLH LKFIAGFGVR LLAAANFTFK VFRAPEPLEL TLPVELLADT RVTQSSIRTP VVSISACSLF SGHANEFDGS NSTSHALLVL VQKHIKAVLS NKLCLSISNL VQGVNVHLGT LIGLNPVGPE SQIRYSMVSV PTVTSDYISL EVNAVLFLLG KPIILPTDAT PFVLPRHVGT EGSMATVGLS QQLFDSALLL LQKAGALNLD ITGQLRSDDN LLNTSALGRL IPEVARQFPE PMPVVLKVRL GATPVAMLHT NNATLRLQPF VEVLATASNS AFQSLFSLDV VVNLRLQLSV SKVKLQGTTS VLGDVQLTVA SSNVGFIDTD QVRTLMGTVF EKPLLDHLNA LLAMGIALPG VVNLHYVAPE IFVYEGYVVI SSGLFYQS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards