RING finger protein 175 (RNF175)

About RING finger protein 175

RING finger protein 175 (RNF175) is a protein from Homo sapiens identified by UniProt accession Q8N4F7, 328 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	RING finger protein 175
UniProt accession	Q8N4F7
Gene	RNF175
Organism	Homo sapiens
Length	328 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

facial morphology measurement · score 0.27
nose morphology measurement · score 0.27
brain measurement · score 0.23
cortical surface area measurement · score 0.21
grip strength measurement · score 0.19
neuroimaging measurement · score 0.19
macula measurement · score 0.18
pulse wave reflection index measurement · score 0.15
DNA methylation · score 0.15
FEV/FVC ratio · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N4F7-F1	alphafold	PREDICTED	83.33	—

Amino-acid sequence (328 residues)

MAAGTAARKA APVLEAPPQQ EQLSHTKLSA EDTWNLQQER MYKMHRGHDS MHVEMILIFL CVLVIAQIVL VQWRQRHGRS YNLVTLLQMW VVPLYFTIKL YWWRFLSMWG MFSVITSYIL FRATRKPLSG RTPRLVYKWF LLIYKLSYAF GVVGYLAIMF TMCGFNLFFK IKARDSMDFG IVSLFYGLYY GVMGRDFAEI CSDYMASTIG FYSVSRLPTR SLSDNICAVC GQKIIVELDE EGLIENTYQL SCNHVFHEFC IRGWCIVGKK QTCPYCKEKV DLKRMISNPW ERTHFLYGQI LDWLRYLVAW QPVVIGIVQG IIYSLGLE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards