About Intraflagellar transport protein 70B
Intraflagellar transport protein 70B (IFT70B) is a protein
from Homo sapiens identified by UniProt accession
Q8N4P2, 665 residues long.
MolForge cross-references it against 0 known binders and
8 disease associations.
Target properties
| Protein name | Intraflagellar transport protein 70B |
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| UniProt accession | Q8N4P2 |
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| Gene | IFT70B |
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| Organism | Homo sapiens |
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| Length | 665 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (8)
Diseases linked to this target (Open Targets).
- vital capacity · score 0.27
- forced expiratory volume · score 0.11
- body fat percentage · score 0.05
- neuronal ceroid lipofuscinosis 1 · score 0.04
- familial isolated congenital asplenia · score 0.04
- ependymoma · score 0.02
- refractive error · score 0.02
- ciliopathy · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N4P2-F1 | alphafold | PREDICTED | 92.76 | — |
Amino-acid sequence (665 residues)
MAGLSGAQIP DGEFTAVVYR LIRNARYAEA VQLLGGELQR SPRSRAGLSL LGYCYYRLQE FALAAECYEQ LGQLHPELEQ YRLYQAQALY KACLYAEATR VAFLLLDNPA YHSRVLRLQA AIKYSEGDLP GSRSLVEQLP SREGGEESGG ENETDGQINL GCLLYKEGQY EAACSKFFAA LQASGYQPDL SYNLALAYYS SRQYASALKH IAEIIERGIR QHPELGVGMT TEGIDVRSVG NTLVLHQTAL VEAFNLKAAI EYQLRNYEAA QEALTDMPPR AEEELDPVTL HNQALMNMDA RPTEGFEKLQ FLLQQNPFPP ETFGNLLLLY CKYEYFDLAA DVLAENAHLI YKFLTPYLYD FLDAVITCQT APEEAFIKLD GLAGMLTEVL RKLTIQVQEA RHNRDDEAIK KAVNEYDETM EKYIPVLMAQ AKIYWNLENY PMVEKIFRKS VEFCNDHDVW KLNVAHVLFM QENKYKEAIG FYEPIVKKHY DNILNVSAIV LANLCVSYIM TSQNEEAEEL MRKIEKEEEQ LSYDDPDKKM YHLCIVNLVI GTLYCAKGNY DFGISRVIKS LEPYNKKLGT DTWYYAKRCF LSLLENMSKH TIMLRDSVIQ ECVQFLEHCE LHGRNIPAVI EQPLEEERMH VGKNTVTYES RQLKALIYEI IGWNI
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