Guanosine-3',5'-bis(diphosphate)…

About Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (HDDC3) is a protein from Homo sapiens identified by UniProt accession Q8N4P3, 179 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
UniProt accession	Q8N4P3
Gene	HDDC3
Organism	Homo sapiens
Length	179 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.12
mean platelet volume · score 0.11
neoplasm · score 0.08
Hyperlipoproteinemia type 1 · score 0.05
acute myeloid leukemia · score 0.04
hemochromatosis type 2B · score 0.04
sideroblastic anemia 3 · score 0.04
familial apolipoprotein C-II deficiency · score 0.04
progressive familial intrahepatic cholestasis · score 0.04
Congenital bile acid synthesis defect type 1 · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N4P3-F1	alphafold	PREDICTED	97.94	—

Amino-acid sequence (179 residues)

MGSEAAQLLE AADFAARKHR QQRRKDPEGT PYINHPIGVA RILTHEAGIT DIVVLQAALL HDTVEDTDTT LDEVELHFGA QVRRLVEEVT DDKTLPKLER KRLQVEQAPH SSPGAKLVKL ADKLYNLRDL NRCTPEGWSE HRVQEYFEWA AQVVKGLQGT NRQLEEALKH LFKQRGLTI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (HDDC3)