About Synaptic vesicle 2-related protein
Synaptic vesicle 2-related protein (SVOP) is a protein
from Homo sapiens identified by UniProt accession
Q8N4V2, 548 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Synaptic vesicle 2-related protein |
|---|
| UniProt accession | Q8N4V2 |
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| Gene | SVOP |
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| Organism | Homo sapiens |
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| Length | 548 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (50)
Diseases linked to this target (Open Targets).
- Benign familial chorea · score 0.07
- platelet count · score 0.06
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.06
- hemoglobin D disease · score 0.05
- Ataxia - oculomotor apraxia type 1 · score 0.05
- delta-beta-thalassemia · score 0.05
- hemoglobin E-beta-thalassemia syndrome · score 0.05
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.05
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.05
- cystatin C measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N4V2-F1 | alphafold | PREDICTED | 78.43 | — |
Amino-acid sequence (548 residues)
MEEDLFQLRQ LPVVKFRRTG ESARSEDDTA SGEHEVQIEG VHVGLEAVEL DDGAAVPKEF ANPTDDTFMV EDAVEAIGFG KFQWKLSVLT GLAWMADAME MMILSILAPQ LHCEWRLPSW QVALLTSVVF VGMMSSSTLW GNISDQYGRK TGLKISVLWT LYYGILSAFA PVYSWILVLR GLVGFGIGGV PQSVTLYAEF LPMKARAKCI LLIEVFWAIG TVFEVVLAVF VMPSLGWRWL LILSAVPLLL FAVLCFWLPE SARYDVLSGN QEKAIATLKR IATENGAPMP LGKLIISRQE DRGKMRDLFT PHFRWTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCGI SSRKKAVEAK CSLACEYLSE EDYMDLLWTT LSEFPGVLVT LWIIDRLGRK KTMALCFVIF SFCSLLLFIC VGRNVLTLLL FIARAFISGG FQAAYVYTPE VYPTATRALG LGTCSGMARV GALITPFIAQ VMLESSVYLT LAVYSGCCLL AALASCFLPI ETKGRGLQES SHREWGQEMV GRGMHGAGVT RSNSGSQE
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