About Serine/threonine-protein kinase DCLK2
Serine/threonine-protein kinase DCLK2 (DCLK2) is a protein
from Homo sapiens identified by UniProt accession
Q8N568, 766 residues long.
MolForge cross-references it against 0 known binders and
48 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase DCLK2 |
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| UniProt accession | Q8N568 |
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| Gene | DCLK2 |
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| Organism | Homo sapiens |
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| Length | 766 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (48)
Diseases linked to this target (Open Targets).
- longitudinal alcohol consumption measurement · score 0.41
- alcohol use disorder measurement · score 0.41
- coronary artery disease · score 0.33
- metabolic syndrome · score 0.29
- psychological resilience measurement · score 0.23
- cholelithiasis · score 0.20
- leukocyte count · score 0.19
- alkaline phosphatase measurement · score 0.19
- vital capacity · score 0.17
- neutrophil count · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N568-F1 | alphafold | PREDICTED | 69.60 | — |
Amino-acid sequence (766 residues)
MASTRSIELE HFEERDKRPR PGSRRGAPSS SGGSSSSGPK GNGLIPSPAH SAHCSFYRTR TLQALSSEKK AKKARFYRNG DRYFKGLVFA ISSDRFRSFD ALLIELTRSL SDNVNLPQGV RTIYTIDGSR KVTSLDELLE GESYVCASNE PFRKVDYTKN INPNWSVNIK GGTSRALAAA SSVKSEVKES KDFIKPKLVT VIRSGVKPRK AVRILLNKKT AHSFEQVLTD ITEAIKLDSG VVKRLCTLDG KQVTCLQDFF GDDDVFIACG PEKFRYAQDD FVLDHSECRV LKSSYSRSSA VKYSGSKSPG PSRRSKSPAS VNGTPSSQLS TPKSTKSSSS SPTSPGSFRG LKQISAHGRS SSNVNGGPEL DRCISPEGVN GNRCSESSTL LEKYKIGKVI GDGNFAVVKE CIDRSTGKEF ALKIIDKAKC CGKEHLIENE VSILRRVKHP NIIMLVEEME TATELFLVME LVKGGDLFDA ITSSTKYTER DGSAMVYNLA NALRYLHGLS IVHRDIKPEN LLVCEYPDGT KSLKLGDFGL ATVVEGPLYT VCGTPTYVAP EIIAETGYGL KVDIWAAGVI TYILLCGFPP FRSENNLQED LFDQILAGKL EFPAPYWDNI TDSAKELISQ MLQVNVEARC TAGQILSHPW VSDDASQENN MQAEVTGKLK QHFNNALPKQ NSTTTGVSVI MNTALDKEGQ IFCSKHCQDS GRPGMEPISP VPPSVEEIPV PGEAVPAPTP PESPTPHPPP AAPGGERAGT WRRHRD
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