About Oxidation resistance protein 1
Oxidation resistance protein 1 (OXR1) is a protein
from Homo sapiens identified by UniProt accession
Q8N573, 874 residues long.
MolForge cross-references it against 0 known binders and
109 disease associations.
Target properties
| Protein name | Oxidation resistance protein 1 |
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| UniProt accession | Q8N573 |
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| Gene | OXR1 |
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| Organism | Homo sapiens |
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| Length | 874 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (109)
Diseases linked to this target (Open Targets).
- isolated cerebellar hypoplasia/agenesis · score 0.61
- Hearing impairment · score 0.26
- reticulocyte count · score 0.19
- genetic disorder · score 0.19
- sensorineural hearing loss · score 0.18
- C-reactive protein measurement · score 0.13
- mean corpuscular volume · score 0.11
- neutrophil count · score 0.10
- neutrophil percentage of leukocytes · score 0.10
- reticulocyte measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N573-F1 | alphafold | PREDICTED | 59.73 | — |
Amino-acid sequence (874 residues)
MTKDKNSPGL KKKSQSVDIN APGFNPLAGA GKQTPQASKP PAPKTPIIEE EQNNAANTQK HPSRRSELKR FYTIDTGQKK TLDKKDGRRM SFQKPKGTIE YTVESRDSLN SIALKFDTTP NELVQLNKLF SRAVVTGQVL YVPDPEYVSS VESSPSLSPV SPLSPTSSEA EFDKTTNPDV HPTEATPSST FTGIRPARVV SSTSEEEEAF TEKFLKINCK YITSGKGTVS GVLLVTPNNI MFDPHKNDPL VQENGCEEYG IMCPMEEVMS AAMYKEILDS KIKESLPIDI DQLSGRDFCH SKKMTGSNTE EIDSRIRDAG NDSASTAPRS TEESLSEDVF TESELSPIRE ELVSSDELRQ DKSSGASSES VQTVNQAEVE SLTVKSESTG TPGHLRSDTE HSTNEVGTLC HKTDLNNLEM AIKEDQIADN FQGISGPKED STSIKGNSDQ DSFLHENSLH QEESQKENMP CGETAEFKQK QSVNKGKQGK EQNQDSQTEA EELRKLWKTH TMQQTKQQRE NIQQVSQKEA KHKITSADGH IESSALLKEK QRHRLHKFLC LRVGKPMRKT FVSQASATMQ QYAQRDKKHE YWFAVPQERT DHLYAFFIQW SPEIYAEDTG EYTREPGFIV VKKIEESETI EDSSNQAAAR EWEVVSVAEY HRRIDALNTE ELRTLCRRLQ ITTREDINSK QVATVKADLE SESFRPNLSD PSELLLPDQI EKLTKHLPPR TIGYPWTLVY GTGKHGTSLK TLYRTMTGLD TPVLMVIKDS DGQVFGALAS EPLKVSDGFY GTGETFVFTF CPEFEVFKWT GDNMFFIKGD MDSLAFGGGG GEFALWLDGD LYHGRSHSCK TFGNRTLSKK EDFFIQDIEI WAFE
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