About Tetratricopeptide repeat protein 39C
Tetratricopeptide repeat protein 39C (TTC39C) is a protein
from Homo sapiens identified by UniProt accession
Q8N584, 583 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | Tetratricopeptide repeat protein 39C |
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| UniProt accession | Q8N584 |
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| Gene | TTC39C |
|---|
| Organism | Homo sapiens |
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| Length | 583 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (45)
Diseases linked to this target (Open Targets).
- leukocyte count · score 0.45
- neutrophil count · score 0.45
- neurodegenerative disease · score 0.43
- body height · score 0.33
- myeloid white cell count · score 0.31
- monocyte percentage of leukocytes · score 0.31
- BMI-adjusted waist circumference · score 0.29
- primary familial polycythemia due to EPO receptor mutation · score 0.05
- hemolytic anemia due to diphosphoglycerate mutase deficiency · score 0.05
- erythrocytosis, familial, 3 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N584-F1 | alphafold | PREDICTED | 85.44 | — |
Amino-acid sequence (583 residues)
MAGSEQQRPR RRDDGDSDAA AAAAAPLQDA ELALAGINML LNNGFRESDQ LFKQYRNHSP LMSFGASFVS FLNAMMTFEE EKMQLACDDL KTTEKLCESE EAGVIETIKN KIKKNVDVRK SAPSMVDRLQ RQIIIADCQV YLAVLSFVKQ ELSAYIKGGW ILRKAWKIYN KCYLDINALQ ELYQKKLTEE SLTSDAANDN HIVAEGVSEE SLNRLKGAVS FGYGLFHLCI SMVPPNLLKI INLLGFPGDR LQGLSSLMYA SESKDMKAPL ATLALLWYHT VVRPFFALDG SDNKAGLDEA KEILLKKEAA YPNSSLFMFF KGRIQRLECQ INSALTSFHT ALELAVDQRE IQHVCLYEIG WCSMIELNFK DAFDSFERLK NESRWSQCYY AYLTAVCQGA TGDVDGAQIV FKEVQKLFKR KNNQIEQFSV KKAERFRKQT PTKALCVLAS IEVLYLWKAL PNCSFPNLQR MSQACHEVDD SSVVGLKYLL LGAIHKCLGN SEDAVQYFQR AVKDELCRQN NLYVQPYACY ELGCLLLDKP ETVGRGRALL LQAKEDFSGY DFENRLHVRI HAALASLREL VPQ
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