MPN domain-containing protein (MPND)

About MPN domain-containing protein

MPN domain-containing protein (MPND) is a protein from Homo sapiens identified by UniProt accession Q8N594, 471 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	MPN domain-containing protein
UniProt accession	Q8N594
Gene	MPND
Organism	Homo sapiens
Length	471 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

mean corpuscular hemoglobin · score 0.19
hematocrit · score 0.08
protein measurement · score 0.07
mean corpuscular volume · score 0.06
Red cell distribution width · score 0.05
hemoglobin measurement · score 0.04
monocyte count · score 0.04
erythrocyte count · score 0.03
cortical surface area measurement · score 0.03
lean body mass · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N594-F1	alphafold	PREDICTED	70.22	—

Amino-acid sequence (471 residues)

MAAPEPLSPA GGAGEEAPEE DEDEAEAEDP ERPNAGAGGG RSGGGGSSVS GGGGGGGAGA GGCGGPGGAL TRRAVTLRVL LKDALLEPGA GVLSIYYLGK KFLGDLQPDG RIMWQETGQT FNSPSAWATH CKKLVNPAKK SGCGWASVKY KGQKLDKYKA TWLRLHQLHT PATAADESPA SEGEEEELLM EEEEEDVLAG VSAEDKSRRP LGKSPSEPAH PEATTPGKRV DSKIRVPVRY CMLGSRDLAR NPHTLVEVTS FAAINKFQPF NVAVSSNVLF LLDFHSHLTR SEVVGYLGGR WDVNSQMLTV LRAFPCRSRL GDAETAAAIE EEIYQSLFLR GLSLVGWYHS HPHSPALPSL QDIDAQMDYQ LRLQGSSNGF QPCLALLCSP YYSGNPGPES KISPFWVMPP PEMLLVEFYK GSPDLVRLQE PWSQEHTYLD KLKISLASRT PKDQSLCHVL EQVCGVLKQG S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards