About E3 ubiquitin-protein ligase RNF10
E3 ubiquitin-protein ligase RNF10 (RNF10) is a protein
from Homo sapiens identified by UniProt accession
Q8N5U6, 811 residues long.
MolForge cross-references it against 0 known binders and
189 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF10 |
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| UniProt accession | Q8N5U6 |
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| Gene | RNF10 |
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| Organism | Homo sapiens |
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| Length | 811 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (189)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.51
- reticulocyte measurement · score 0.49
- Immature Reticulocyte Fraction Measurement · score 0.29
- electrocardiography · score 0.27
- Red cell distribution width · score 0.21
- chronotype measurement · score 0.20
- mathematical ability · score 0.19
- mean corpuscular volume · score 0.16
- mean reticulocyte volume · score 0.15
- vital capacity · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N5U6-F1 | alphafold | PREDICTED | 64.57 | — |
Amino-acid sequence (811 residues)
MPLSSPNAAA TASDMDKNSG SNSSSASSGS SKGQQPPRSA SAGPAGESKP KSDGKNSSGS KRYNRKRELS YPKNESFNNQ SRRSSSQKSK TFNKMPPQRG GGSSKLFSSS FNGGRRDEVA EAQRAEFSPA QFSGPKKINL NHLLNFTFEP RGQTGHFEGS GHGSWGKRNK WGHKPFNKEL FLQANCQFVV SEDQDYTAHF ADPDTLVNWD FVEQVRICSH EVPSCPICLY PPTAAKITRC GHIFCWACIL HYLSLSEKTW SKCPICYSSV HKKDLKSVVA TESHQYVVGD TITMQLMKRE KGVLVALPKS KWMNVDHPIH LGDEQHSQYS KLLLASKEQV LHRVVLEEKV ALEQQLAEEK HTPESCFIEA AIQELKTREE ALSGLAGSRR EVTGVVAALE QLVLMAPLAK ESVFQPRKGV LEYLSAFDEE TTEVCSLDTP SRPLALPLVE EEEAVSEPEP EGLPEACDDL ELADDNLKEG TICTESSQQE PITKSGFTRL SSSPCYYFYQ AEDGQHMFLH PVNVRCLVRE YGSLERSPEK ISATVVEIAG YSMSEDVRQR HRYLSHLPLT CEFSICELAL QPPVVSKETL EMFSDDIEKR KRQRQKKARE ERRRERRIEI EENKKQGKYP EVHIPLENLQ QFPAFNSYTC SSDSALGPTS TEGHGALSIS PLSRSPGSHA DFLLTPLSPT ASQGSPSFCV GSLEEDSPFP SFAQMLRVGK AKADVWPKTA PKKDENSLVP PAPVDSDGES DNSDRVPVPS FQNSFSQAIE AAFMKLDTPA TSDPLSEEKG GKKRKKQKQK LLFSTSVVHT K
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