About Meiosis-specific with OB domain-containing protein
Meiosis-specific with OB domain-containing protein (MEIOB) is a protein
from Homo sapiens identified by UniProt accession
Q8N635, 442 residues long.
MolForge cross-references it against 0 known binders and
133 disease associations.
Target properties
| Protein name | Meiosis-specific with OB domain-containing protein |
|---|
| UniProt accession | Q8N635 |
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| Gene | MEIOB |
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| Organism | Homo sapiens |
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| Length | 442 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (133)
Diseases linked to this target (Open Targets).
- spermatogenic failure 22 · score 0.63
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.38
- azoospermia · score 0.35
- body height · score 0.23
- mean corpuscular hemoglobin · score 0.22
- mean corpuscular volume · score 0.13
- triple-negative breast cancer · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.07
- monocyte count · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N635-F1 | alphafold | PREDICTED | 80.88 | — |
Amino-acid sequence (442 residues)
MANSFAARIF TTLSDLQTNM ANLKVIGIVI GKTDVKGFPD RKNIGSERYT FSFTIRDSPA HFVNAASWGN EDYIKSLSDS FRVGDCVIIE NPLIQRKEIE REEKFSPATP SNCKLLLSEN HSTVKVCSSY EVDTKLLSLI HLPVKESHDY YSLGDIVANG HSLNGRIINV LAAVKSVGEP KYFTTSDRRK GQRCEVRLYD ETESSFAMTC WDNESILLAQ SWMPRETVIF ASDVRINFDK FRNCMTATVI SKTIITTNPD IPEANILLNF IRENKETNVL DDEIDSYFKE SINLSTIVDV YTVEQLKGKA LKNEGKADPS YGILYAYIST LNIDDETTKV VRNRCSSCGY IVNEASNMCT TCNKNSLDFK SVFLSFHVLI DLTDHTGTLH SCSLTGSVAE ETLGCTFVLS HRARSGLKIS VLSCKLADPT EASRNLSGQK HV
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