About COMM domain-containing protein 1
COMM domain-containing protein 1 (COMMD1) is a protein
from Homo sapiens identified by UniProt accession
Q8N668, 190 residues long.
MolForge cross-references it against 0 known binders and
103 disease associations.
Target properties
| Protein name | COMM domain-containing protein 1 |
|---|
| UniProt accession | Q8N668 |
|---|
| Gene | COMMD1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 190 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (103)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- Age-related nuclear cataract · score 0.31
- mean corpuscular volume · score 0.29
- erythrocyte count · score 0.16
- hemoglobin measurement · score 0.15
- mean reticulocyte volume · score 0.14
- red blood cell density measurement · score 0.14
- mean corpuscular hemoglobin · score 0.13
- mean corpuscular hemoglobin concentration · score 0.12
- amino acid measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N668-F1 | alphafold | PREDICTED | 86.37 | — |
Amino-acid sequence (190 residues)
MAAGELEGGK PLSGLLNALA QDTFHGYPGI TEELLRSQLY PEVPPEEFRP FLAKMRGILK SIASADMDFN QLEAFLTAQT KKQGGITSDQ AAVISKFWKS HKTKIRESLM NQSRWNSGLR GLSWRVDGKS QSRHSAQIHT PVAIIELELG KYGQESEFLC LEFDEVKVNQ ILKTLSEVEE SISTLISQPN
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