About Zinc finger and BTB domain-containing protein 2
Zinc finger and BTB domain-containing protein 2 (ZBTB2) is a protein
from Homo sapiens identified by UniProt accession
Q8N680, 514 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | Zinc finger and BTB domain-containing protein 2 |
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| UniProt accession | Q8N680 |
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| Gene | ZBTB2 |
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| Organism | Homo sapiens |
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| Length | 514 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (44)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- monocyte count · score 0.40
- appendicular lean mass · score 0.37
- lean body mass · score 0.24
- sex hormone-binding globulin measurement · score 0.23
- leukocyte count · score 0.23
- fat body mass · score 0.20
- myeloid white cell count · score 0.18
- base metabolic rate measurement · score 0.15
- whole body water mass · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N680-F1 | alphafold | PREDICTED | 56.61 | — |
Amino-acid sequence (514 residues)
MDLANHGLIL LQQLNAQREF GFLCDCTVAI GDVYFKAHKS VLASFSNYFK MLFVHQTSEC VRLKPTDIQP DIFSYLLHLM YTGKMAPQLI DPVRLEQGIK FLHAYPLIQE ASLASQGAFS HPDQVFPLAS SLYGIQIADH QLRQATKIAS APEKLGRDPR PQTSRISQEQ VPEASQLSQL TSNLAQVNRT NMTPSDPLQT SLSPELVSTP VPPPPPGEET NLEASSSDEQ PASLTIAHVK PSIMKRNGSF PKYYACHLCG RRFTLRSSLR EHLQIHTGVP FTSSQQGESR VPLTLCSNAA DLGKDAMEVP EAGMISDSEL QHISDSPIID GQQQSETPPP SDIADIDNLE QADQEREVKR RKYECTICGR KFIQKSHWRE HMYIHTGKPF KCSTCDKSFC RANQAARHVC LNQSIDTYTM VDKQTLELCT FEEGSQMDNM LVQTNKPYKC NLCDKTFSTP NEVVKHSCQN QNSDVFALDE GRSILLGSGD SEVTEPDHPV LASIKKEQET VLLD
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