About Cleavage and polyadenylation specificity factor subunit 7
Cleavage and polyadenylation specificity factor subunit 7 (CPSF7) is a protein
from Homo sapiens identified by UniProt accession
Q8N684, 471 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | Cleavage and polyadenylation specificity factor subunit 7 |
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| UniProt accession | Q8N684 |
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| Gene | CPSF7 |
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| Organism | Homo sapiens |
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| Length | 471 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (61)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- prostate cancer · score 0.11
- prostate carcinoma · score 0.11
- Familial prostate cancer · score 0.11
- lung adenocarcinoma · score 0.07
- early-onset non-syndromic cataract · score 0.07
- Cataract-microcornea syndrome · score 0.06
- Total congenital cataract · score 0.06
- isolated ectopia lentis · score 0.06
- Cataract with Y-shaped suture opacities · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N684-F1 | alphafold | PREDICTED | 65.84 | — |
Amino-acid sequence (471 residues)
MSEGVDLIDI YADEEFNQDP EFNNTDQIDL YDDVLTATSQ PSDDRSSSTE PPPPVRQEPS PKPNNKTPAI LYTYSGLRNR RAAVYVGSFS WWTTDQQLIQ VIRSIGVYDV VELKFAENRA NGQSKGYAEV VVASENSVHK LLELLPGKVL NGEKVDVRPA TRQNLSQFEA QARKRECVRV PRGGIPPRAH SRDSSDSADG RATPSENLVP SSARVDKPPS VLPYFNRPPS ALPLMGLPPP PIPPPPPLSS SFGVPPPPPG IHYQHLMPPP PRLPPHLAVP PPGAIPPALH LNPAFFPPPN ATVGPPPDTY MKASAPYNHH GSRDSGPPPS TVSEAEFEDI MKRNRAISSS AISKAVSGAS AGDYSDAIET LLTAIAVIKQ SRVANDERCR VLISSLKDCL HGIEAKSYSV GASGSSSRKR HRSRERSPSR SRESSRRHRD LLHNEDRHDD YFQERNREHE RHRDRERDRH H
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