Beta-defensin 125 (DEFB125)

About Beta-defensin 125

Beta-defensin 125 (DEFB125) is a protein from Homo sapiens identified by UniProt accession Q8N687, 156 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	Beta-defensin 125
UniProt accession	Q8N687
Gene	DEFB125
Organism	Homo sapiens
Length	156 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.28
lung adenocarcinoma · score 0.24
cutaneous melanoma · score 0.23
endometrial cancer · score 0.21
glioblastoma multiforme · score 0.20
ovarian cancer · score 0.18
squamous cell lung carcinoma · score 0.17
menopause · score 0.17
gastric adenocarcinoma · score 0.14
breast adenocarcinoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N687-F1	alphafold	PREDICTED	62.94	—

Amino-acid sequence (156 residues)

MNILMLTFII CGLLTRVTKG SFEPQKCWKN NVGHCRRRCL DTERYILLCR NKLSCCISII SHEYTRRPAF PVIHLEDITL DYSDVDSFTG SPVSMLNDLI TFDTTKFGET MTPETNTPET TMPPSEATTP ETTMPPSETA TSETMPPPSQ TALTHN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards