Beta-defensin 119 (DEFB119)

About Beta-defensin 119

Beta-defensin 119 (DEFB119) is a protein from Homo sapiens identified by UniProt accession Q8N690, 84 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.

Target properties

Protein name	Beta-defensin 119
UniProt accession	Q8N690
Gene	DEFB119
Organism	Homo sapiens
Length	84 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (30)

Diseases linked to this target (Open Targets).

lung adenocarcinoma · score 0.24
cutaneous melanoma · score 0.23
endometrial cancer · score 0.21
gastric adenocarcinoma · score 0.14
adolescent idiopathic scoliosis · score 0.10
breast adenocarcinoma · score 0.10
gastric carcinoma · score 0.08
Female infertility due to fertilization defect · score 0.08
Rare genetic female infertility · score 0.07
female infertility due to oocyte meiotic arrest · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N690-F1	alphafold	PREDICTED	74.46	—

Amino-acid sequence (84 residues)

MKLLYLFLAI LLAIEEPVIS GKRHILRCMG NSGICRASCK KNEQPYLYCR NCQSCCLQSY MRISISGKEE NTDWSYEKQW PRLP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards