About Solute carrier family 15 member 4
Solute carrier family 15 member 4 (SLC15A4) is a protein
from Homo sapiens identified by UniProt accession
Q8N697, 577 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | Solute carrier family 15 member 4 |
|---|
| UniProt accession | Q8N697 |
|---|
| Gene | SLC15A4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 577 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (70)
Diseases linked to this target (Open Targets).
- systemic lupus erythematosus · score 0.36
- basophil count · score 0.29
- basophil percentage of leukocytes · score 0.24
- gut microbiome measurement · score 0.17
- cutaneous melanoma · score 0.13
- Systemic lupus erythematosus · score 0.08
- ulcerative colitis · score 0.07
- inflammatory bowel disease · score 0.05
- drug use measurement · score 0.05
- lung adenocarcinoma · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N697-F1 | alphafold | PREDICTED | 84.77 | — |
Amino-acid sequence (577 residues)
MEGSGGGAGE RAPLLGARRA AAAAAAAGAF AGRRAACGAV LLTELLERAA FYGITSNLVL FLNGAPFCWE GAQASEALLL FMGLTYLGSP FGGWLADARL GRARAILLSL ALYLLGMLAF PLLAAPATRA ALCGSARLLN CTAPGPDAAA RCCSPATFAG LVLVGLGVAT VKANITPFGA DQVKDRGPEA TRRFFNWFYW SINLGAILSL GGIAYIQQNV SFVTGYAIPT VCVGLAFVVF LCGQSVFITK PPDGSAFTDM FKILTYSCCS QKRSGERQSN GEGIGVFQQS SKQSLFDSCK MSHGGPFTEE KVEDVKALVK IVPVFLALIP YWTVYFQMQT TYVLQSLHLR IPEISNITTT PHTLPAAWLT MFDAVLILLL IPLKDKLVDP ILRRHGLLPS SLKRIAVGMF FVMCSAFAAG ILESKRLNLV KEKTINQTIG NVVYHAADLS LWWQVPQYLL IGISEIFASI AGLEFAYSAA PKSMQSAIMG LFFFFSGVGS FVGSGLLALV SIKAIGWMSS HTDFGNINGC YLNYYFFLLA AIQGATLLLF LIISVKYDHH RDHQRSRANG VPTSRRA
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