About Casein kinase I isoform alpha-like
Casein kinase I isoform alpha-like (CSNK1A1L) is a protein
from Homo sapiens identified by UniProt accession
Q8N752, 337 residues long.
MolForge cross-references it against 0 known binders and
11 disease associations.
Target properties
| Protein name | Casein kinase I isoform alpha-like |
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| UniProt accession | Q8N752 |
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| Gene | CSNK1A1L |
|---|
| Organism | Homo sapiens |
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| Length | 337 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (11)
Diseases linked to this target (Open Targets).
- neuroinflammatory disorder · score 0.19
- neurodegenerative disease · score 0.18
- coronary artery calcification · score 0.06
- CCL4 measurement · score 0.06
- ulcerative colitis · score 0.01
- lung adenocarcinoma · score 0.01
- cancer · score 0.01
- Sepsis · score 0.01
- neoplasm · score 0.00
- Crohn's disease · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N752-F1 | alphafold | PREDICTED | 91.46 | — |
Amino-acid sequence (337 residues)
MTNNSGSKAE LVVGGKYKLV RKIGSGSFGD VYLGITTTNG EDVAVKLESQ KVKHPQLLYE SKLYTILQGG VGIPHMHWYG QEKDNNVLVM DLLGPSLEDL FNFCSRRFTM KTVLMLADQM ISRIEYVHTK NFLHRDIKPD NFLMGTGRHC NKLFLIDFGL AKKYRDNRTR QHIPYREDKH LIGTVRYASI NAHLGIEQSR RDDMESLGYV FMYFNRTSLP WQGLRAMTKK QKYEKISEKK MSTPVEVLCK GFPAEFAMYL NYCRGLRFEE VPDYMYLRQL FRILFRTLNH QYDYTFDWTM LKQKAAQQAA SSSGQGQQAQ TQTGKQTEKN KNNVKDN
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