Probable E3 ubiquitin-protein ligase TRIML2 (TRIML2)

About Probable E3 ubiquitin-protein ligase TRIML2

Probable E3 ubiquitin-protein ligase TRIML2 (TRIML2) is a protein from Homo sapiens identified by UniProt accession Q8N7C3, 437 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	Probable E3 ubiquitin-protein ligase TRIML2
UniProt accession	Q8N7C3
Gene	TRIML2
Organism	Homo sapiens
Length	437 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.30
metabolite measurement · score 0.29
unipolar depression · score 0.19
response to selective serotonin reuptake inhibitor · score 0.19
adolescent idiopathic scoliosis · score 0.16
xanthine measurement · score 0.15
pathological myopia · score 0.14
neurofibrillary tangles measurement · score 0.11
breast milk measurement · score 0.11
age at menopause · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N7C3-F1	alphafold	PREDICTED	85.98	—

Amino-acid sequence (437 residues)

MSKRLSPQLQ HNITEDAYCE THLEPTRLFC DVDQITLCSK CFQSQEHKHH MVCGIQEAAE NYRKLFQEIL NTSREKLEAA KSILTDEQER MAMIQEEEQN FKKMIESEYS MRLRLLNEEC EQNLQRQQEC ISDLNLRETL LNQAIKLATE LEEMFQEMLQ RLGRVGRENM EKLKESEARA SEQVRSLLKL IVELEKKCGE GTLALLKNAK YSLERSKSLL LEHLEPAHIT DLSLCHIRGL SSMFRVLQRH LTLDPETAHP CLALSEDLRT MRLRHGQQDG AGNPERLDFS AMVLAAESFT SGRHYWEVDV EKATRWQVGI YHGSADAKGS TARASGEKVL LTGSVMGTEW TLWVFPPLKR LFLEKKLDTV GVFLDCEHGQ ISFYNVTEMS LIYNFSHCAF QGALRPVFSL CIPNGDTSPD SLTILQHGPS CDATVSP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards