Putative E3 ubiquitin-protein ligase UBR7 (UBR7)

About Putative E3 ubiquitin-protein ligase UBR7

Putative E3 ubiquitin-protein ligase UBR7 (UBR7) is a protein from Homo sapiens identified by UniProt accession Q8N806, 425 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	Putative E3 ubiquitin-protein ligase UBR7
UniProt accession	Q8N806
Gene	UBR7
Organism	Homo sapiens
Length	425 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

Li-Campeau syndrome · score 0.60
hypothyroidism · score 0.47
Intellectual disability · score 0.46
epilepsy · score 0.46
complex neurodevelopmental disorder · score 0.37
autosomal recessive non-syndromic intellectual disability · score 0.37
Intellectual disability, mild · score 0.33
Global developmental delay · score 0.11
neoplasm · score 0.08
hepatocellular carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N806-F1	alphafold	PREDICTED	75.36	—

Amino-acid sequence (425 residues)

MAGAEGAAGR QSELEPVVSL VDVLEEDEEL ENEACAVLGG SDSEKCSYSQ GSVKRQALYA CSTCTPEGEE PAGICLACSY ECHGSHKLFE LYTKRNFRCD CGNSKFKNLE CKLLPDKAKV NSGNKYNDNF FGLYCICKRP YPDPEDEIPD EMIQCVVCED WFHGRHLGAI PPESGDFQEM VCQACMKRCS FLWAYAAQLA VTKISTEDDG LVRNIDGIGD QEVIKPENGE HQDSTLKEDV PEQGKDDVRE VKVEQNSEPC AGSSSESDLQ TVFKNESLNA ESKSGCKLQE LKAKQLIKKD TATYWPLNWR SKLCTCQDCM KMYGDLDVLF LTDEYDTVLA YENKGKIAQA TDRSDPLMDT LSSMNRVQQV ELICEYNDLK TELKDYLKRF ADEGTVVKRE DIQQFFEEFQ SKKRRRVDGM QYYCS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards