About Protein disulfide-isomerase-like protein of the testis
Protein disulfide-isomerase-like protein of the testis (PDILT) is a protein
from Homo sapiens identified by UniProt accession
Q8N807, 584 residues long.
MolForge cross-references it against 0 known binders and
129 disease associations.
Target properties
| Protein name | Protein disulfide-isomerase-like protein of the testis |
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| UniProt accession | Q8N807 |
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| Gene | PDILT |
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| Organism | Homo sapiens |
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| Length | 584 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (129)
Diseases linked to this target (Open Targets).
- glomerular filtration rate · score 0.48
- creatinine measurement · score 0.47
- blood urea nitrogen measurement · score 0.42
- chronic kidney disease · score 0.41
- blood protein measurement · score 0.41
- hypertension · score 0.40
- cystatin C measurement · score 0.38
- urolithiasis · score 0.37
- systolic blood pressure · score 0.37
- Agents acting on the renin-angiotensin system use measurement · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N807-F1 | alphafold | PREDICTED | 84.66 | — |
Amino-acid sequence (584 residues)
MDLLWMPLLL VAACVSAVHS SPEVNAGVSS IHITKPVHIL EERSLLVLTP AGLTQMLNQT RFLMVLFHNP SSKQSRNLAE ELGKAVEIMG KGKNGIGFGK VDITIEKELQ QEFGITKAPE LKLFFEGNRS EPISCKGVVE SAALVVWLRR QISQKAFLFN SSEQVAEFVI SRPLVIVGFF QDLEEEVAEL FYDVIKDFPE LTFGVITIGN VIGRFHVTLD SVLVFKKGKI VNRQKLINDS TNKQELNRVI KQHLTDFVIE YNTENKDLIS ELHIMSHMLL FVSKSSESYG IIIQHYKLAS KEFQNKILFI LVDADEPRNG RVFKYFRVTE VDIPSVQILN LSSDARYKMP SDDITYESLK KFGRSFLSKN ATKHQSSEEI PKYWDQGLVK QLVGKNFNVV VFDKEKDVFV MFYAPWSKKC KMLFPLLEEL GRKYQNHSTI IIAKIDVTAN DIQLMYLDRY PFFRLFPSGS QQAVLYKGEH TLKGFSDFLE SHIKTKIEDE DELLSVEQNE VIEEEVLAEE KEVPMMRKGL PEQQSPELEN MTKYVSKLEE PAGKKKTSEE VVVVVAKPKG PPVQKKKPKV KEEL
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