Cyclin N-terminal domain-containing protein 1 (CNTD1)

About Cyclin N-terminal domain-containing protein 1

Cyclin N-terminal domain-containing protein 1 (CNTD1) is a protein from Homo sapiens identified by UniProt accession Q8N815, 330 residues long. MolForge cross-references it against 0 known binders and 113 disease associations.

Target properties

Protein name	Cyclin N-terminal domain-containing protein 1
UniProt accession	Q8N815
Gene	CNTD1
Organism	Homo sapiens
Length	330 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (113)

Diseases linked to this target (Open Targets).

BMI-adjusted waist circumference · score 0.19
azoospermia · score 0.10
partial chromosome Y deletion · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.08
spermatogenic failures 50 · score 0.08
spermatogenic failure 25 · score 0.08
isochromosomy Yp · score 0.07
spermatogenic failure, X-linked, 2 · score 0.07
spermatogenic failure 63 · score 0.07
spermatogenic failure 61 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N815-F1	alphafold	PREDICTED	84.55	—

Amino-acid sequence (330 residues)

MDGPMRPRSA SLVDFQFGVV ATETIEDALL HLAQQNEQAV REASGRLGRF REPQIVEFVF LLSEQWCLEK SVSYQAVEIL ERFMVKQAEN ICRQATIQPR DNKRESQNWR ALKQQLVNKF TLRLVSCVQL ASKLSFRNKI ISNITVLNFL QALGYLHTKE ELLESELDVL KSLNFRINLP TPLAYVETLL EVLGYNGCLV PAMRLHATCL TLLDLVYLLH EPIYESLLRA SIENSTPSQL QGEKFTSVKE DFMLLAVGII AASAFIQNHE CWSQVVGHLQ SITGIALASI AEFSYAILTH GVGANTPGRQ QSIPPHLAAR ALKTVASSNT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards