About Tubulin polyglutamylase TTLL6
Tubulin polyglutamylase TTLL6 (TTLL6) is a protein
from Homo sapiens identified by UniProt accession
Q8N841, 891 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Tubulin polyglutamylase TTLL6 |
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| UniProt accession | Q8N841 |
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| Gene | TTLL6 |
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| Organism | Homo sapiens |
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| Length | 891 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (47)
Diseases linked to this target (Open Targets).
- pulse pressure measurement · score 0.30
- cystatin C measurement · score 0.19
- Barrett's esophagus · score 0.08
- blood protein measurement · score 0.07
- chronotype measurement · score 0.07
- platelet count · score 0.07
- systolic blood pressure · score 0.06
- alkaline phosphatase measurement · score 0.06
- coronary artery disease · score 0.06
- lean body mass · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N841-F1 | alphafold | PREDICTED | 60.42 | — |
Amino-acid sequence (891 residues)
MGALLLHPSR RGPAGVVASW TSSPAGRDGG VGIAGAWYFP RASSQAREMP QCPTLESQEG ENSEEKGDSS KEDPKETVAL AFVRENPGAQ NGLQNAQQQG KKKRKKKRLV INLSSCRYES VRRAAQQYGF REGGEDDDWT LYWTDYSVSL ERVMEMKSYQ KINHFPGMSE ICRKDLLARN MSRMLKMFPK DFRFFPRTWC LPADWGDLQT YSRSRKNKTY ICKPDSGCQG KGIFITRTVK EIKPGEDMIC QLYISKPFII DGFKFDLRIY VLVTSCDPLR IFVYNEGLAR FATTSYSRPC TDNLDDICMH LTNYSINKHS SNFSRDAHSG SKRKLSTFSA YLEDHSYNVE QIWRDIEDVI IKTLISAHPI IRHNYHTCFP NHTLNSACFE ILGFDILLDH KLKPWLLEVN HSPSFSTDSR LDKEVKDGLL YDTLVLINLE SCDKKKVLEE ERQRGQFLQQ CCSREMRIEE AKGFRAVQLK KTETYEKENC GGFRLIYPSL NSEKYEKFFQ DNNSLFQNTV ASRAREEYAR QLIQELRLKR EKKPFQMKKK VEMQGESAGE QVRKKGMRGW QQKQQQKDKA ATQASKQYIQ PLTLVSYTPD LLLSVRGERK NETDSSLNQE APTEEASSVF PKLTSAKPFS SLPDLRNINL SSSKLEPSKP NFSIKEAKSA SAVNVFTGTV HLTSVETTPE STTQLSISPK SPPTLAVTAS SEYSGPETDR VVSFKCKKQQ TPPHLTQKKM LKSFLPTKSK SFWESPNTNW TLLKSDMNKP HLISELLTKL QLSGKLSFFP AHYNPKLGMN NLSQNPSLPG ECHSRSDSSG EKRQLDVSSL LLQSPQSYNV TLRDLLVIAT PAQLDPRPCR SHASAMRDPC MQDQEAYSHC LISGQKGCER S
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