About APC membrane recruitment protein 3
APC membrane recruitment protein 3 (AMER3) is a protein
from Homo sapiens identified by UniProt accession
Q8N944, 861 residues long.
MolForge cross-references it against 0 known binders and
9 disease associations.
Target properties
| Protein name | APC membrane recruitment protein 3 |
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| UniProt accession | Q8N944 |
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| Gene | AMER3 |
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| Organism | Homo sapiens |
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| Length | 861 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (9)
Diseases linked to this target (Open Targets).
- Tracheoesophageal fistula · score 0.26
- neurodegenerative disease · score 0.24
- central nervous system cancer · score 0.03
- Ataxia-telangiectasia · score 0.02
- Barrett's esophagus · score 0.02
- small cell lung carcinoma · score 0.01
- type 2 diabetes mellitus · score 0.00
- Esophageal atresia · score 0.00
- neoplasm · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N944-F1 | alphafold | PREDICTED | 44.71 | — |
Amino-acid sequence (861 residues)
MELKRGKTFI KSSLQVSHEK PPDPAAVAAA REGTGPWSVL PGGQQRPHSE KGPQASPSAQ EYDRCPNKGA QLDPKGGPAA LCGATFKPVR KCKTHDSMSG AGRATAATGQ LVGSASFPGS PGSRRMIDYR HFVPQMPFVP AVAKSIPRKR ISLKRPKKCF RNLFHIRRNK TEDLASLAAE GKSLPSPGDP SDPGGRRSKA FLPPGEGPGL DGLCQDLLDS ELLADASFGL CRALCEDVAS LQSFDSLTGC GEVFADESSV PSLELNEGPE SPTQAAQGLE SKVPRGPLQG SVEQLASPAQ NEASDFTRFW DSVNRSVRQQ QRALLGPWLS GPQGTDRDQS RLDTAGLAEL PLCPCRDPRS GSKASSIDTG TPKSEQPESV STSDEGYYDS FSPGLEEDKK EAESPGTPAA TFPRDSYSGD ALYELFHDPS EGPLGPSPDD DLCVSESLSG PALGTPLSIC SFRVGAEENL APAPGPDLLS QGFLQSSWKG KECLLKLCDT ELAITMGIVS WLRRGPTPRA PPTPGQPAAP PGSQGAPRAP TEKLGGREGL ASDAGGATVC SAPSRQELWA HPGTTGLLAG ESKALGGATQ GTGTLSRDAS REEETRGHSE GLFSSMESAA TSTTDTSGKN KAPVPSTWPC SQKEPGPPGV LGCFRGPWRP GHGGDTLDAE PMLAGCVARV AALKISSNEQ PPAAWPPRQD MGSGLFGQRW ARGPDMLEQK QSSSSPSMTT IHGLPYSAST QDQRCRDRVQ DLSWLRVEPT GLGVQAWASV EDQPLQLSTE AVEQVAHGSQ LDSEPRSAPA ARWSSQGHHP ESLGLTLNSQ QEGGVSASAP ECRCSLLARE GLLCGQPEVG ASGPAMAEPH L
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