About Large ribosomal subunit protein mL43
Large ribosomal subunit protein mL43 (MRPL43) is a protein
from Homo sapiens identified by UniProt accession
Q8N983, 215 residues long.
MolForge cross-references it against 0 known binders and
40 disease associations.
Target properties
| Protein name | Large ribosomal subunit protein mL43 |
|---|
| UniProt accession | Q8N983 |
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| Gene | MRPL43 |
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| Organism | Homo sapiens |
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| Length | 215 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (40)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- serum gamma-glutamyl transferase measurement · score 0.16
- retinal nerve fibre layer thickness measurement · score 0.13
- mean platelet volume · score 0.12
- lean body mass · score 0.08
- blood phosphate measurement · score 0.08
- blood urea nitrogen measurement · score 0.08
- body weight · score 0.06
- alkaline phosphatase measurement · score 0.06
- vital capacity · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N983-F1 | alphafold | PREDICTED | 82.75 | — |
Amino-acid sequence (215 residues)
MTARGTPSRF LASVLHNGLG RYVQQLQRLS FSVSRDGASS RGAREFVERE VIDFARRNPG VVIYVNSRPC CVPRVVAEYL NGAVREESIH CKSVEEISTL VQKLADQSGL DVIRIRKPFH TDNPSIQGQW HPFTNKPTTF RGLRPREVQD PAPAQDTGLR LSAVAPQILL PGWPDPPDLP TVDPISSSLT SAPAPMLSAV SCLPIVPALT TVCSA
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