N-terminal EF-hand calcium-binding protein 1 (NECAB1)

About N-terminal EF-hand calcium-binding protein 1

N-terminal EF-hand calcium-binding protein 1 (NECAB1) is a protein from Homo sapiens identified by UniProt accession Q8N987, 351 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.

Target properties

Protein name	N-terminal EF-hand calcium-binding protein 1
UniProt accession	Q8N987
Gene	NECAB1
Organism	Homo sapiens
Length	351 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (56)

Diseases linked to this target (Open Targets).

body fat percentage · score 0.32
smoking behaviour measurement · score 0.22
age at first sexual intercourse measurement · score 0.21
self reported educational attainment · score 0.19
serum metabolite measurement · score 0.19
smoking status measurement · score 0.15
smoking initiation · score 0.11
hematocrit · score 0.10
hemoglobin measurement · score 0.07
insomnia measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N987-F1	alphafold	PREDICTED	79.11	—

Amino-acid sequence (351 residues)

MEDSQETSPS SNNSSEELSS ALHLSKGMSI FLDILRRADK NDDGKLSFEE FKAYFADGVL SGEELHELFH TIDTHNTNNL DTEELCEYFS QHLGEYENVL AALEDLNLSI LKAMGKTKKD YQEASNLEQF VTRFLLKETL NQLQSLQNSL ECAMETTEEQ TRQERQGPAK PEVLSIQWPG KRSSRRVQRH NSFSPNSPQF NVSGPGLLEE DNQWMTQINR LQKLIDRLEK KDLKLEPPEE EIIEGNTKSH IMLVQRQMSV IEEDLEEFQL ALKHYVESAS SQSGCLRISI QKLSNESRYM IYEFWENSSV WNSHLQTNYS KTFQRSNVDF LETPELTSTM LVPASWWILN N

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards