About Lethal(3)malignant brain tumor-like protein 4
Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4) is a protein
from Homo sapiens identified by UniProt accession
Q8NA19, 623 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Lethal(3)malignant brain tumor-like protein 4 |
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| UniProt accession | Q8NA19 |
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| Gene | L3MBTL4 |
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| Organism | Homo sapiens |
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| Length | 623 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (53)
Diseases linked to this target (Open Targets).
- refractive error · score 0.32
- hypertension · score 0.32
- neurodegenerative disease · score 0.31
- physical activity · score 0.28
- Abnormality of refraction · score 0.25
- Alzheimer disease · score 0.25
- Parkinson disease · score 0.25
- lysosomal storage disease · score 0.25
- multiple sclerosis · score 0.25
- bilirubin measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NA19-F1 | alphafold | PREDICTED | 74.81 | — |
Amino-acid sequence (623 residues)
MKQPNRKRKL NMDSKERLDQ DGRLEQAEEE KKPKDSTTPL SHVPSAAAQG AWSWEWYLKE QKAVAAPVEL FSKDQSFPEH ENGFQIGMRL EGIDPRHPSV FCVLSVAEVC GYRLRLHFDG YLSCYDFWTN AGSPDIHPVG WCEKTKHELH IPKGYRKDKF VWMDYLKACK LQNAPKKLFR NRSPNGPMSK EFQVGMKLEA VDRKNPSLVC VATIADIVED RLLVHFDNWD DSYDYWCDVN SPYVQPVGWC QENGRTLIAP QGYPNPENFS WTEYLEATQT NAVPAKVFKM RLPHGFLPNM KLEVVDKRNP RLIRVATIVD VDDQRVKVHF DGWDHKYDYW VEADSPDIHP IGWCDVTGHP LEVPQRTNDL KILPGQAVCP TPGCRGIGHI RGPRYSGHHS AFGCPYSDMN LKKEATLHDR LREQTQANLE SDSSHSKSKS LCSLNFNGKH EKVNSQPRLV QQAKCLKIKG KEDIDLDNLF RVLVLHPRGL EYSVEQAQQV LHQSVSMSTV SAHPFRDLPL GREQHCKLLP GVADIRASQV ARWTVDEVAE FVQSLLGCEE HAKCFKKEQI DGKAFLLLTQ TDIVKVMKIK LGPALKIYNS ILMFRHSQEL PEEDIASGQE VRG
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