About Sodium-dependent lysophosphatidylcholine symporter 1
Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A) is a protein
from Homo sapiens identified by UniProt accession
Q8NA29, 543 residues long.
MolForge cross-references it against 0 known binders and
161 disease associations.
Target properties
| Protein name | Sodium-dependent lysophosphatidylcholine symporter 1 |
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| UniProt accession | Q8NA29 |
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| Gene | MFSD2A |
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| Organism | Homo sapiens |
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| Length | 543 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (161)
Diseases linked to this target (Open Targets).
- autosomal recessive primary microcephaly · score 0.67
- genetic disorder · score 0.41
- Microcephaly · score 0.37
- platelet count · score 0.35
- Red cell distribution width · score 0.35
- cryptorchidism · score 0.35
- hemoglobin measurement · score 0.34
- fetal growth restriction · score 0.33
- Intellectual disability · score 0.33
- Hyperammonemia · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NA29-F1 | alphafold | PREDICTED | 80.62 | — |
Amino-acid sequence (543 residues)
MAKGEGAESG SAAGLLPTSI LQSTERPAQV KKEPKKKKQQ LSVCNKLCYA LGGAPYQVTG CALGFFLQIY LLDVAQKDEE VVFCFSSFQV GPFSASIILF VGRAWDAITD PLVGLCISKS PWTCLGRLMP WIIFSTPLAV IAYFLIWFVP DFPHGQTYWY LLFYCLFETM VTCFHVPYSA LTMFISTEQT ERDSATAYRM TVEVLGTVLG TAIQGQIVGQ ADTPCFQDLN SSTVASQSAN HTHGTTSHRE TQKAYLLAAG VIVCIYIICA VILILGVREQ REPYEAQQSE PIAYFRGLRL VMSHGPYIKL ITGFLFTSLA FMLVEGNFVL FCTYTLGFRN EFQNLLLAIM LSATLTIPIW QWFLTRFGKK TAVYVGISSA VPFLILVALM ESNLIITYAV AVAAGISVAA AFLLPWSMLP DVIDDFHLKQ PHFHGTEPIF FSFYVFFTKF ASGVSLGIST LSLDFAGYQT RGCSQPERVK FTLNMLVTMA PIVLILLGLL LFKMYPIDEE RRRQNKKALQ ALRDEASSSG CSETDSTELA SIL
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