About Telomere repeats-binding bouquet formation protein 1
Telomere repeats-binding bouquet formation protein 1 (TERB1) is a protein
from Homo sapiens identified by UniProt accession
Q8NA31, 727 residues long.
MolForge cross-references it against 0 known binders and
113 disease associations.
Target properties
| Protein name | Telomere repeats-binding bouquet formation protein 1 |
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| UniProt accession | Q8NA31 |
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| Gene | TERB1 |
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| Organism | Homo sapiens |
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| Length | 727 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (113)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.44
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.38
- self reported educational attainment · score 0.12
- blood protein measurement · score 0.08
- high density lipoprotein cholesterol measurement · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.07
- congenital bilateral absence of vas deferens · score 0.06
- primary ovarian insufficiency · score 0.06
- 46,XX testicular disorder of sex development · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NA31-F1 | alphafold | PREDICTED | 71.59 | — |
Amino-acid sequence (727 residues)
MESEDTKKTQ EMKTDLNLLL ECLKYQMDNA FSQKEALVTI HSICQQNSNA SVYFREIGGL MFVKNLAKSS EHSMVKEAAL YTLGAIAEKN VYCQQTLCTS ELFEDLTWFL SNDSNINLKR MSVYVILVLV SNNRTGQTLV RETGCITVLS RLFRTVISKH ELDLSDKNVF QSYQLWSSVC STLCVCVNNP QNDENQMFCC SLFPHANEWL KNCTTPEIIR PICSFIGLTL ANNTYVQKYF VSVGGLDVLS QVLMQLESDS HETLSSAKLA VVVTKTVDAC IADNPTFGIV LSKYHIVSKL LALLLHESLD SGEKFSIMLT LGHCTEDCEE NQYDLFKNNG LPLMIQALTE SQNEELNKAA TFVLHNCKKI TEKLSLSLGE YPFDENETQQ LKDISVKENN LEEHWRKAKE ILHRIEQLER EGNEEEIQRE NYQDNISSMN ISIQNTWKHL HADRIGRGSK AEDEDKSHSR QLQSYKSHGV MSKACTNDDQ MKTPLKSANP VHACYRESEQ NKTLYKAKSS CNQNLHEETT FEKNFVSQSS DHVFKHPVHI AKNIKQQLPV TDPFTLCSDI INKEVVSFLA TPSCSEMLTY RCSGCIAVEK SLNSRNFSKL LHSCPYQCDR HKVIVEAEDR YKSELRKSLI CNKKILLTPR RRQRLSNEST TPGGIKKRRI RKNFTEEEVN YLFNGVKKMG NHWNSILWSF PFQQGRKAVD LAHKYHKLTK HPTCAAS
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