About IQ motif and ubiquitin-like domain-containing protein
IQ motif and ubiquitin-like domain-containing protein (IQUB) is a protein
from Homo sapiens identified by UniProt accession
Q8NA54, 791 residues long.
MolForge cross-references it against 0 known binders and
93 disease associations.
Target properties
| Protein name | IQ motif and ubiquitin-like domain-containing protein |
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| UniProt accession | Q8NA54 |
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| Gene | IQUB |
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| Organism | Homo sapiens |
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| Length | 791 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (93)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.11
- male infertility with teratozoospermia due to single gene mutation · score 0.10
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.09
- spermatogenic failure 49 · score 0.08
- spermatogenic failure 19 · score 0.08
- spermatogenic failure 45 · score 0.08
- spermatogenic failure 43 · score 0.08
- spermatogenic failure 46 · score 0.08
- spermatogenic failure 18 · score 0.08
- spermatogenic failure 27 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NA54-F1 | alphafold | PREDICTED | 75.29 | — |
Amino-acid sequence (791 residues)
MSNQQEKYEA QNIVNSTEES DDAFDTVTIP VPSEEPQESD QTEEHESGIE QFSESHAIHV EEQSDQSFSS LEPDNEQLME EVISPRQVSY TPQHHEKQYA MQRPNDDSLA FLDKIKSVKE SLQESVEDSL ATVKVVLIPV GQEIVIPFKV DTILKYLKDH FSHLLGIPHS VLQIRYSGKI LKNNETLVQH GVKPQEIVQV EIFSTNPDLY PVRRIDGLTD VSQIITVTVQ TGLDQYQQVP VEIVKSDFHK PFLGGFRHKV TGVEYHNAGT QTVPKRIPER LSIFCRDTQT VFQKKNLQQT TNTTSTQMTN IGVYVSNMTD KLVTPGKYFS AAEYHAQRLK AVIVIQTYYR QWHAKIFVEN LRRQKSLRLE WETQQELRKI REKEEWIKLD YHRRHNPKTN EDFEFLYNAL EFWRQEELTR INQSFTGAER KAALCELLEK ETQIIASIGR HRYIAYMANQ EAAIQAFLDK CSAPKIWRTP NGKTIEMDTQ FTIRARELQN IYKCIMLKNI SQDERLDVLL TLKHTVKEHE CKLTQEILEL IDREVDLMMR GVKHHNLEGL RKRIATLFFH YIKTPLFNPE VAKYLKVPQD PLKFYKKIYF CHSCQLYLPS TEFSVSSTSR RIYRCRNCIN LQNEAQKRES FLKYKCLLQQ LYYTEADYED DSKIAFLMQL QDIQYLTENI WASQSVLSAC DNLSDLVMVR WNKSLEWSPW NCILLTKDEA AAHLKLTSIE EGYERSFIHK IKHKHILAKN YFSQVPVLAS FILDDGEIDE IRWKYHSDTT PKIIESQRPP H
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