About Tetratricopeptide repeat protein 29
Tetratricopeptide repeat protein 29 (TTC29) is a protein
from Homo sapiens identified by UniProt accession
Q8NA56, 475 residues long.
MolForge cross-references it against 0 known binders and
139 disease associations.
Target properties
| Protein name | Tetratricopeptide repeat protein 29 |
|---|
| UniProt accession | Q8NA56 |
|---|
| Gene | TTC29 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 475 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (139)
Diseases linked to this target (Open Targets).
- spermatogenic failure 42 · score 0.60
- smoking status measurement · score 0.42
- self reported educational attainment · score 0.41
- smoking initiation · score 0.40
- mathematical ability · score 0.39
- non-syndromic male infertility due to sperm motility disorder · score 0.37
- attention deficit hyperactivity disorder · score 0.30
- substance abuse · score 0.30
- antisocial behaviour measurement · score 0.30
- cognitive function measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NA56-F1 | alphafold | PREDICTED | 84.79 | — |
Amino-acid sequence (475 residues)
MTTLPPLPMT RPKLTALARQ KLPCSSRKIP RSQLIKEKDD IDHYLEVNFK GLSKEEVAAY RNSYKKNICV DMLRDGYHKS FTELFALMER WDALREAARV RSLFWLQKPL EEQPDKLDYL YHYLTRAEDA ERKESFEDVH NNLYALACYF NNSEDKWVRN HFYERCFKIA QLIKIDCGKK EAEAHMHMGL LYEEDGQLLE AAEHYEAFHQ LTQGRIWKDE TGRSLNLLAC ESLLRTYRLL SDKMLENKEY KQAIKILIKA SEIAKEGSDK KMEAEASYYL GLAHLAAEEY ETALTVLDTY CKISTDLDDD LSLGRGYEAI AKVLQSQGEM TEAIKYLKKF VKIARNNFQS LDLVRASTML GDIYNEKGYY NKASECFQQA FDTTVELMSM PLMDETKVHY GIAKAHQMML TVNNYIESAD LTSLNYLLSW KESRGNIEPD PVTEEFRGST VEAVSQNSER LEELSRFPGD QKNET
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