About Cyclic nucleotide-binding domain-containing protein 1
Cyclic nucleotide-binding domain-containing protein 1 (CNBD1) is a protein
from Homo sapiens identified by UniProt accession
Q8NA66, 436 residues long.
MolForge cross-references it against 0 known binders and
127 disease associations.
Target properties
| Protein name | Cyclic nucleotide-binding domain-containing protein 1 |
|---|
| UniProt accession | Q8NA66 |
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| Gene | CNBD1 |
|---|
| Organism | Homo sapiens |
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| Length | 436 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (127)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.28
- smoking status measurement · score 0.25
- body weight · score 0.19
- neoplasm · score 0.19
- hepatocellular carcinoma · score 0.18
- myelodysplastic syndrome · score 0.18
- chronic lymphocytic leukemia · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- breast carcinoma · score 0.18
- acute myeloid leukemia · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NA66-F1 | alphafold | PREDICTED | 71.66 | — |
Amino-acid sequence (436 residues)
MPMSSLPAAI LSHMTAINNV PPPPLHSIPN LKKSKHINYG QLNALCHIRG QHSRSMSNIL SAHDTFMKQY PKVFLHQKPR LPKLFKQEEQ RELNEGKEES QHQQPDDSNN IAVHVQRAHG GHILYRPKRA TEKFEEFLAI LKKLPIHRTP YEHKTVWKFL KTIPDLTFQL NDKHLKTLSK TVFSETWLKG STVVANDGFY VILKGLARPQ TNVYKNLIEG SDSPDSFISQ SFHSFIWSEE FKNSTLAEMY LPSYDSMLSK WSTFGTLEVM PQNESETQMF SVVTEDDCEI LKIPAKGYAK IKEEKIKLEN MQKLKLIRMC PYYEEWPTLS IYELIALLKW KKFPPGHVIV ESGNIISFVG YINSGCCNIY RSIIGFVKLR SNKVKRSQKL VYMGKLKEKE SFGEISVLLQ VPFTCTIITK KEVEMAIIED KDLFVA
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