DDB1- and CUL4-associated factor 4-like protein 2…

About DDB1- and CUL4-associated factor 4-like protein 2

DDB1- and CUL4-associated factor 4-like protein 2 (DCAF4L2) is a protein from Homo sapiens identified by UniProt accession Q8NA75, 395 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.

Target properties

Protein name	DDB1- and CUL4-associated factor 4-like protein 2
UniProt accession	Q8NA75
Gene	DCAF4L2
Organism	Homo sapiens
Length	395 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (25)

Diseases linked to this target (Open Targets).

cleft lip · score 0.37
Cleft palate · score 0.35
optic disc area measurement · score 0.30
neurodegenerative disease · score 0.27
Orofacial cleft · score 0.25
progranulin measurement · score 0.24
brain measurement · score 0.23
cortical surface area measurement · score 0.21
cortical thickness · score 0.21
optic disc size measurement · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NA75-F1	alphafold	PREDICTED	85.12	—

Amino-acid sequence (395 residues)

MESKRPRLLE EADKQKKTVR VGLNAPSMLR KNQLGFLRFA NYCRIARELR VSCMQRKKVQ IHSWDPSSLA SDRFNRILAN TNTDQLFTVN QVEAGGSKYG IITMRGLTTP ELRVYPHKTL YVPNRKVNSM CWASLNHLDS HLLLCFVGLA DTPSCAVLLP ASLFIGSFPG MRRPGMLCSF QIPDAWSCAW SLSIHAYHSF STGLSQQVLL TNVVTGHQQS FGTSSDVLAQ QFAIMTPLLF NGCRSGEIFG IDLRCGNQGS GWKAICLSHD SAVTSLQILQ DGQFLVSSDM TGTIKLWDLR ATKCVTQYEG HVNNSAYLPV HVNEEEGVVA AVGQDCYTRI WSLRHGHLLT TIPSPYPASE NDIPSVAFSS RLGGFRGAPG LLMAVREDLY CFSYG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

DDB1- and CUL4-associated factor 4-like protein 2 (DCAF4L2)