About Probable E3 ubiquitin-protein ligase MARCHF10
Probable E3 ubiquitin-protein ligase MARCHF10 (MARCHF10) is a protein
from Homo sapiens identified by UniProt accession
Q8NA82, 808 residues long.
MolForge cross-references it against 0 known binders and
14 disease associations.
Target properties
| Protein name | Probable E3 ubiquitin-protein ligase MARCHF10 |
|---|
| UniProt accession | Q8NA82 |
|---|
| Gene | MARCHF10 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 808 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (14)
Diseases linked to this target (Open Targets).
- wellbeing measurement · score 0.31
- neuroticism measurement · score 0.31
- depressive symptom measurement · score 0.31
- systolic blood pressure · score 0.04
- pulse pressure measurement · score 0.04
- diastolic blood pressure · score 0.03
- respiratory system cancer · score 0.02
- papillary thyroid carcinoma · score 0.01
- lung adenocarcinoma · score 0.01
- influenza · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NA82-F1 | alphafold | PREDICTED | 49.78 | — |
Amino-acid sequence (808 residues)
MLHDARDRQK FFSDVQYLRD MQHKVDSEYQ ACLRRQEYRR DPNEKKRDQF WGQETSFERS RFSSRSSSKQ SSSEEDALTE PRSSIKISAF KCDSKLPAID QTSVKQKHKS TMTVRKAEKV DPSEPSPADQ APMVLLRKRK PNLRRFTVSP ESHSPRASGD RSRQKQQWPA KVPVPRGADQ VVQQEGLMCN TKLKRPNQER RNLVPSSQPM TENAPDRAKK GDPSAPSQSE LHPALSQAFQ GKNSPQVLSE FSGPPLTPTT VGGPRKASFR FRDEDFYSIL SLNSRRESDD TEEETQSEEC LWVGVRSPCS PSHHKRSRFG GTSTPQAKNK NFEENAENCR GHSSRRSEPS HGSLRISNAM EPATERPSAG QRLSQDPGLP DRESATEKDR GGSENAKKSP LSWDTKSEPR QEVGVNAENV WSDCISVEHR PGTHDSEGYW KDYLNSSQNS LDYFISGRPI SPRSSVNSSY NPPASFMHSA LRDDIPVDLS MSSTSVHSSD SEGNSGFHVC QPLSPIRNRT PFASAENHNY FPVNSAHEFA VREAEDTTLT SQPQGAPLYT DLLLNPQGNL SLVDSSSSSP SRMNSEGHLH VSGSLQENTP FTFFAVSHFP NQNDNGSRMA ASGFTDEKET SKIKADPEKL KKLQESLLEE DSEEEGDLCR ICQIAGGSPS NPLLEPCGCV GSLQFVHQEC LKKWLKVKIT SGADLGAVKT CEMCKQGLLV DLGDFNMIEF YQKHQQSQAQ NELMNSGLYL VLLLHLYEQR FAELMRLNHN QVERERLSRN YPQPRTEENE NSELGDGNEG SISQSQVV
Explore Probable E3 ubiquitin-protein ligase MARCHF10 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets