THAP domain-containing protein 8 (THAP8)

About THAP domain-containing protein 8

THAP domain-containing protein 8 (THAP8) is a protein from Homo sapiens identified by UniProt accession Q8NA92, 274 residues long. MolForge cross-references it against 0 known binders and 5 disease associations.

Target properties

Protein name	THAP domain-containing protein 8
UniProt accession	Q8NA92
Gene	THAP8
Organism	Homo sapiens
Length	274 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (5)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.09
diet measurement · score 0.06
membranous glomerulonephritis · score 0.06
infection · score 0.00
infect · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NA92-F1	alphafold	PREDICTED	71.90	—

Amino-acid sequence (274 residues)

MPKYCRAPNC SNTAGRLGAD NRPVSFYKFP LKDGPRLQAW LQHMGCEHWV PSCHQHLCSE HFTPSCFQWR WGVRYLRPDA VPSIFSRGPP AKSQRRTRST QKPVSPPPPL QKNTPLPQSP AIPVSGPVRL VVLGPTSGSP KTVATMLLTP LAPAPTPERS QPEVPAQQAQ TGLGPVLGAL QRRVRRLQRC QERHQAQLQA LERLAQQLHG ESLLARARRG LQRLTTAQTL GPEESQTFTI ICGGPDIAMV LAQDPAPATV DAKPELLDTR IPSA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards