About Kelch repeat and BTB domain-containing protein 3
Kelch repeat and BTB domain-containing protein 3 (KBTBD3) is a protein
from Homo sapiens identified by UniProt accession
Q8NAB2, 612 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | Kelch repeat and BTB domain-containing protein 3 |
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| UniProt accession | Q8NAB2 |
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| Gene | KBTBD3 |
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| Organism | Homo sapiens |
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| Length | 612 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (29)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- protein measurement · score 0.22
- mathematical ability · score 0.05
- age at first sexual intercourse measurement · score 0.05
- self reported educational attainment · score 0.05
- cognitive function measurement · score 0.05
- myeloperoxidase deficiency · score 0.04
- Blackfan-Diamond anemia · score 0.04
- neutropenia, severe congenital, 2, autosomal dominant · score 0.04
- Recurrent infection due to specific granule deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NAB2-F1 | alphafold | PREDICTED | 89.75 | — |
Amino-acid sequence (612 residues)
MELAMDNSYA FNQRSTCNGI PSEKKNNFLV SEDHGQKILS VLQNFREQNV FYDFKIIMKD EIIPCHRCVL AACSDFFRAM FEVNMKERDD GSVTITNLSS KAVKAFLDYA YTGKTKITDD NVEMFFQLSS FLQVSFLSKA CSDFLIKSIN LVNCLQLLSI SDSYGSTSLF DHALHFVQHH FSLLFKSSDF LEMNFGVLQK CLESDELNVP EEEMVLKVVL SWTKHNLESR QKYLPHLIEK VRLHQLSEET LQDCLFNEES LLKSTNCFDI IMDAIKCVQG SGGLFPDARP STTEKYIFIH KTEENGENQY TFCYNIKSDS WKILPQSHLI DLPGSSLSSY GEKIFLTGGC KGKCCRTVRL HIAESYHDAT DQTWCYCPVK NDFFLVSTMK TPRTMHTSVM ALDRLFVIGG KTRGSRDIKS LLDVESYNPL SKEWISVSPL PRGIYYPEAS TCQNVIYVLG SEVEITDAFN PSLDCFFKYN ATTDQWSELV AEFGQFFHAT LIKAVPVNCT LYICDLSTYK VYSFCPDTCV WKGEGSFECA GFNAGAIGIE DKIYILGGDY APDEITDEVQ VYHSNRSEWE EVSPMPRALT EFYCQVIQFN KYRDPWFSNL CA
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