About Zinc finger protein 579
Zinc finger protein 579 (ZNF579) is a protein
from Homo sapiens identified by UniProt accession
Q8NAF0, 562 residues long.
MolForge cross-references it against 0 known binders and
17 disease associations.
Target properties
| Protein name | Zinc finger protein 579 |
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| UniProt accession | Q8NAF0 |
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| Gene | ZNF579 |
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| Organism | Homo sapiens |
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| Length | 562 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (17)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- Parkinson disease · score 0.31
- multiple sclerosis · score 0.31
- lysosomal storage disease · score 0.31
- Alzheimer disease · score 0.31
- triglyceride measurement · score 0.12
- plasma fibronectin deficiency · score 0.07
- isolated asymptomatic elevation of creatine phosphokinase · score 0.06
- Hereditary persistence of alpha-fetoprotein · score 0.04
- congenital enteropathy due to enteropeptidase deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NAF0-F1 | alphafold | PREDICTED | 60.84 | — |
Amino-acid sequence (562 residues)
MDPQPPPPAQ GSPPHRGRGR GRGRGRGRGR GRGRGGAGAP RAPLPCPTCG RLFRFPYYLS RHRLSHSGLR PHACPLCPKA FRRPAHLSRH LRGHGPQPPL RCAACPRTFP EPAQLRRHLA QEHAGGEVEL AIERVAKETA EPSWGPQDEG SEPPTTAAAG ATEEEAVAAW PETWPAGEPS TLAAPTSAAE PRESESEEAE AGAAELRAEL ALAAGRQEEK QVLLQADWTL LCLRCREAFA TKGELKAHPC LRPEGEQEGE GGPPPRPKRH QCSICLKAFA RPWSLSRHRL VHSTDRPFVC PDCGLAFRLA SYLRQHRRVH GPLSLLAPLP AAGKKDDKAS GARNSAKGPE GGEGAECGGA SEGGEGQNGG DAAPARPPAG EPRFWCPECG KGFRRRAHLR QHGVTHSGAR PFQCVRCQRE FKRLADLARH AQVHAGGPAP HPCPRCPRRF SRAYSLLRHQ RCHRAELERA AALQALQAQA PTSPPPPPPP LKAEQEEEGL PLPLANIKEE PPSPGTPPQS PPAPPVFLSA SCFDSQDHSA FEMEEEEVDS KAHLRGLGGL AS
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